Comparative study on clinical efficacy between Artesunte and Quinine in the treatment of Cerebral Malaria
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 5
Abstract
Malaria remains a serious helath problem in tropical regions causing 0.86 million death in 2009. Quinine is still effective against Plasmodium falciparum (P.f) but in recent years rising trends of resistance is emerging in sense of response time, and fever clearance time. The objective of the study was to compare the clinical efficacy of Artesunate with Quinine in the treatment of cerebral malaria. The study was conducted on 50 confirmed patients of cerebral malaria in the Department of Medicine in Katihar Medical College, Katihar, Bihar. Diagnosis was confirmed clinically on the basis of World Health Organization (WHO) criteria, positive blood films and by Parahit total rapid dipstick for malaria. Patients were randomized to receive either Artesunate or Quinine. Our study shows that 68% of patients treated with Artesunate improved with in 8-24 hrs against 16% from Quinine. There were no serious side effects noted in patients who are treated with Artesunate while 44% of the patients who are treated with Quinine developed side effects. Our study suggests that Artesunate is a good alternative to Quinine in the treatment for cerebral malaria and can be used as first line treatment.
Authors and Affiliations
Shafat Imam Siddiqui
Keywords
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