COMPARATIVE STUDY ON EFFECT OF SOLID DISPERSION TECHNIQUES FOR ENHANCEMENT OF DISSOLUTION RATE OF PIOGLITAZONE HCl
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 8
Abstract
Pioglitazone hydrochloride is a novel antidiabetic drug in thiazolidinediones group and it improves insulin sensitivity in insulin resistant patients. One of the major problems with this drug is its low solubility in biological fluids, which results into poor bioavailability after oral administration. The present study is an attempt to enhance the dissolution rate of pioglitazone HCl by kneading and physical mixture techniques using pioglitazone HCl and β-cyclodextrine as carrier in the ratios of 1:1, 1:2 and 1:3 respectively. The drug carrier interaction study was carried out by Fourier Transform Infrared Spectroscopy (FTIR). The prepared solid dispersions were characterized for percentage yield, bulk density, tapped density, Carr’s Index, Hausner’s ratio, angle of repose, drug content, drug dissolution and stability study. The FTIR study suggesting no interaction between drug and carrier of solid dispersion. The kneading and physical mixture techniques were found to be efficient method to obtained good yield solid dispersions with good flow properties. The drug content was found in the ranges of 77.2±0.28 to 88.8±0.19 %. Dissolution study revealed that there is marked enhancement in the dissolution rate of pioglitazone from all the solid dispersions when compared to pure pioglitazone itself. From the in vitro drug release profile, it can be seen that formulation F1 (1:1 ratio of drug: β-cyclodextrine, prepared by kneading technique) shows higher dissolution rate compared with other formulations. All pioglitazone solid dispersions were found to be stable in various storage temperatures. The kneading is suitable method for development of solid dispersion of pioglitazone HCl.
Authors and Affiliations
Sruti Mishra , Ellaiah P. , Prabhat Jena , Bhabani Nayak , Gitanjali Mishra
Keywords
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