Comparative Study on Liver Enzymes (ALT & AST) In the Intermittent and Daily Regimen Therapy in Patients of Tuberculosis
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 4
Abstract
Tuberculosis (Tb) Which Is One Of The Oldest Diseases Known To Affect Humans And Is Likely A Major Cause Of Death Worldwide1 .Of The Standard Antitubercular Drug Used In Dots Strategy And Non-Dots Strategy, Isoniazid, Rifampicin And Pyrazinamide Metabolized By Liver By Different Enzymatic Reaction And Have Been Associated With Development Of Drug Induced Hepatotoxicity. The Population Residing In Jharkhand State Are Tribal People (27.6%) Who Are Not Only Economically, Socially And Educationally Backward But They Mostly Believe In The Orthodox Treatment Of Even Most Severe And Complicated Disease. The Incidence And Prevalence Of Pulmonary Tuberculosis In These Tribal Belts Are Alarming. The Good Compliance And The Ensured Institution Of Drugs For Tuberculosis Will Certainly Increase The Cure Rate Of Disease. The Intermittent Short-Course Therapy Would Certainly Have A Good Impact On The Facts. Most Of The Patients On Daily Regimen Therapy Discontinue Their Treatment And Turn To Be Treatment Failure Case.The Present Study Was Carried Out In 200 Cases Receiving Category 1 Therapy. Patients Were Selected From Outdoor Patients And Indoor Patients From The Department Of Medicine And Tb & Chest Unit, Rajendra Institute Of Medical Sciences, Ranchi From October 2016 To September 2017.On The Basis Of Above Observation Made In The Prospective Cohort Study, It Can Be Concluded That Liver Enzyme Alteration Is Most Common Finding In The Patient Receiving Anti-Tubercular Chemotherapy. Revised Who Regimen, Directly Observed Therapy Short (Dots) Course Is Most Cost-Effective Therapeutic Programme, Especially For Developing Countries Like India.
Authors and Affiliations
DrRajeshwar Rao, Dr. Bindey Kumar, DrJeewan Kumar Mitra
Keywords
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- EP ID EP370452
- DOI 10.9790/0853-1704035663.
- Views 89
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