COMPARATIVE STUDY ON METHANOLIC AND CHLOROFORM EXTRACTS OF TRACHYSPERMUM AMMI SEEDS FOR ANTIARTHRITIC AND ANTIGOUT ACTIVITY.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2018, Vol 6, Issue 1
Abstract
Objective: The objective of the present study is to report the in vitro anti-arthritic and anti-gout activity of methanolic and chloroform extract of Trachyspermum ammi seeds. Materials and Methods: Fresh Trachyspermum ammi seeds were collected and extracted by using methanol and chloroform solvent by successive soxhelation for the constituents. Preliminary phytochemical screening has been done. Methanolic extract was tested for its polyphenolic content by Folin-ciocalteu\\\'s reagent. In vitro anti-arthritic activity was performed by inhibition of protein denaturation method. In vitro anti-gout activity was performed by the metal chelating complex assay. Results: The study showed the presence of cardiac glycosides, carbohydrates, phytosterols, saponins, phenolic and tannins in the methanolic extract. Alkaloids, saponins, phenolics, tannins, carbohydrates in chloroform extract. The methanolic extract showed significant anti-arthritic activity than chloroform extract, this might be due to methanolic extract was rich in polyphenols. The anti-gout activity of Trachyspermum ammi seeds methanolic extract was also observed to be highly significant in its activity. Conclusion: Both the methanolic and chloroform extracts of Trachyspermum ammi seeds were found to have significant anti-arthritic and anti-gout activity when compared to standard drug diclofenac in a dose-dependent manner.
Authors and Affiliations
S Ramachandran, J Nikitha, K Srujana
Keywords
Related Articles
- EP ID EP276751
- DOI 10.21474/IJAR01/6419
- Views 103
- Downloads 0
IMPACT OF SMALL GROUP INTERACTIVE EDUCATION, ON CHILDHOOD ASTHMA LEVEL OF CONTROL.
IJAR
THE ROLE OF BUSINESS PARTNERSHIP AND SUPPLY CHAINS MANAGEMENT OF SMALL-MEDIUM ENTERPRISES IN SURABAYA.
SCM will face increasingly serious challenges, as the complexity of consumer demand and intercompany relationships in the value chain are increasing. Research on supply chain analysis and design in enhancing competitive...
STUDY ON THE GROWTH RESPONSE OF PHYSIC NUT TO VARIOUS SOIL TYPES.
A field work has been conducted to study the impact of soil over the growth and seed output of Jatropha (Physic nut) for a period of three years at Krishna district of Andhra Pradesh selecting different Jatropha plantati...
AN EMPERICAL STUDY OF DEMONETIZATION & ITS IMPACT ON RETHINKING OF TAX DISCLOSURE - A STUDY BASED ON NATIONAL CAPITAL REGION.
Demonetization refers to the withdrawal of particular currency (legal tender currency of country) from circulation. Demonetization done to reduce the black money, eradicate fake currency and to promote digital India. Thi...
THE IMPACT OF HEALTH-RELATED PROBLEM ON ACADEMIC ACHIEVEMENT OF STUDENTS: APPLICATION OF DUMMY VARIABLE REGRESSION MODEL
Health is a base for social, cultural and economic development of society. But sometimes attaining this health, unfavorable condition is impossible due to some health problems. The aim of this study is to identify the ma...