Comparative study on the effect of hydrophilic and hydrophobic polymers on the dissolution rate of a poorly water soluble drug
Journal Title: International Journal of Pharmacy and Analytical Research - Year 2014, Vol 3, Issue 3
Abstract
Matrix tablets of controlled release systems were designed by incorporating HPMC (K100M) and Kollidon® SR polymers in order to sustain the release of ketoprofen. All the formulations were prepared by direct compression method. Various pharmaco technical evaluation tests such as uniformity of weight, diameter and thickness, hardness and friability of the tablets were determined for each formulation and the marketed reference product. The effects of different types and concentrations of polymers were also investigated. The dissolution profiles of the formulated tablets were compared to that of the marketed reference Apo-Keto SR® tablets. The in vitro release studies revealed that the release was sustained up to 12 hours in this experiment. The best formulation was selected by obtaining a similarity factor (f2) value of more than 50%, approaching 100%. The release kinetics from each formulation such as first order equation, zero order equation, Higuchi equation, equation and Korsmeyer-Peppas was also studied. The statistical results indicated that there was significant difference between each formulation and they were found to be compatible. At the same polymer content, the most sustained drug released was found to be prepared using HPMC (K100M) rather than Kollidon® SR. It was found that by increasing the polymer content, the rate of drug release decreased. The best formulation was F2 containing 20% HPMC (K100M) polymer as it showed comparable dissolution profile to the reference product with f2 value of 71.94%. The drug release determined using kinetics equations revealed that the drug release follows the diffusion mechanism.
Authors and Affiliations
Jiyauddin K
Keywords
Related Articles
- EP ID EP656142
- DOI -
- Views 57
- Downloads 0
Oral Dispersible Tablets - A Review
The convenience of administration and improved patients compliance are important in the design of oral drug delivery s system which remains the preferred route of drug delivery inspite of various disadvantage.one such pr...
Analytical method development and validation for residual solvent of Diltiazem hydrochloride extended release capsule by Gas chromatography
Residual solvents are organic volatile chemicals that are either used or produced during the manufacture of active pharmaceutical ingredients, excipients, and drug products. Organic solvents such as di ethyl ether, N hep...
In-vivo analgesic, anti-inflammatory and central nervous system - locomotor activities of certain synthesized 2-[(1-((phenyl amino) methyl) substituted 1H-benzoimidazol-2-yl) alkyl] isoindoline-1, 3-diones
Two homologous series of 1, 2-disubstituted benzimidazoles carrying isoindolines (6a-n) were synthesized by mannich type reaction of 2-alkyl benzimidazolyl isoindoline-1,3-dione (4a-b) with different substituted aromatic...
Method Development and Validation of Naftopidil by Reverse Phase-HPLC in Bulk and Pharmaceutical Dosage Forms
A new simple, accurate, rapid and precise isocratic High performance liquid chromatographic (HPLC) method was developed and validated for the determination of Etomidate (ETO) injection. The Method employs Waters HPLC sys...
Analytical method Development and Validation for the estimation of Pioglitazone hydrochloride in Bulk and Tablet dosage form by UV_Spectroscopy
This paper describes the analytical method suitable for validation of Pioglitazone hydrochloride by UV Spectrophotometric method. The method utilized UV spectroscopy and the solvent system was consists of 6 N Glacial ace...