COMPARATIVE STUDY ON THE EFFECTS OF AQUEOUS AND ETHANOL LEAF EXTRACTS OF CASSIA ALATA LINN ON SOME PATHOGENIC BACTERIA AND FUNGI
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 8
Abstract
The plant Cassia alata linn is a shrub that has various uses ranging from mild to severe infectious and non-infectious diseases. The study was aimed at comparing the antimicrobial activities of the aqueous and ethanolic leaf extracts of Cassia alata on bacteria and fungi. The leaf of the plant was collected, dried, macerated and extracted using ethanol and distilled water. The extracts were used for the antibacterial susceptibility testing using agar diffusion. The antimicrobial activity of the water and ethanol extracts against the tested organisms was dose dependent with greater activity against Klebsiella pneumonia, Pseudomonas aeruginosa, Candida albicans and Trichophyton mentagrophytes. The minimum inhibitory concentration of the water extract against the organisms studied was between 1.74 to 7.67 mg, whereas for ethanol extract were 1.26 to 5.23 mg. The ethanol and aqueous extracts of this plant contains phytochemical components which may be responsible for their observed antibacterial effects and this seems to justify the use of the plants in various places for the alleviation of different diseases. The aqueous and ethanol extracts of Cassia alata leaves has been found to exhibit more antimicrobial activities against fungi than bacteria with aqueous leaf extract having better antibacterial activity against Klebsiella pneumoniae, while ethanol leaf extract was on Pseudomonas aeruginosa.
Authors and Affiliations
SY Timothy , CH Wazis , AY Bwala , HJ Bashir , AS Rhoda
Keywords
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