Comparative Study to Assess Clinical Efficacy of Leukotriene Receptor Antagonist and Antihistamines in the Treatment of Allergic Rhinitis
Journal Title: Bengal Journal of Otolaryngology and Head Neck Surgery - Year 2017, Vol 25, Issue 2
Abstract
Introduction Pharmacologic treatment options for allergic rhinitis include intranasal corticosteroids, oral and topical antihistamines, decongestants, intranasal cromolyn, intranasal anticholinergics and leukotriene receptor antagonists. The present study was undertaken to compare the efficacy of leukotriene receptor antagonist and antihistamines in relieving nasal congestion/ obstruction symptom and itching /irritation in eyes.Material and Methods The study was conducted among 125 patients clinically diagnosed suffering from allergic rhinitis Patients were divided into 5 groups and were given oral treatment with oral antihistamines (chlorpheniramine maleate, levocetrizine, fexofenadine, desloratadine) and leukotriene receptor antagonist (montelukast) for a period of 6 weeks. The results were tabulated and analyzed by Chi-square and Kruskal-Wallis test with p value <0.05 as significant value.ResultFor relieving nasal obstruction, levocetrizine group showed maximum improvement at 2 weeks. However, at the end of 6 weeks montelukast group showed maximum relief followed by levocetrizine and desloratidine. In relieving eye itching/irritation, montelukast and levocetirizine were equally effective. Fexofenadine and desloratadine were less effective in relieving nasal obstruction and eye itching/irritation followed by chlorpheniramine maleate, which was least effective.ConclusionAllergic rhinitis affects the social and professional life of patient. Allergen avoidance should be the initial step in the management of allergic rhinitis. Montelukast and levocetirizine are more effective in relieving nasal obstruction and eye itching/irritation compared to fexofenadine, desloratadine and chlorpheniramine maleate.
Authors and Affiliations
Gurpreet Kaur, Rachna Dhingra, Manjinder Singh
Keywords
Related Articles
- EP ID EP433959
- DOI -
- Views 47
- Downloads 0
How We Do It: A DIY Smart Phone based ENT Endoscopy
We present a simple method of preparing a smart phone based ENT endoscopy for OPD clinic and for on call ENT to provide emergency ENT care in Accident and Emergency department when required. In our experience, this metho...
Prevalence and Management of Otitis Media with Effusion Amongst the School Going Children of a Rural Area in Puducherry
Background : Otitis Media with Effusion(OME) also known as Secretory Otitis Media, has been identified as the commonest middle ear condition causing deafness in children in developed countries. Neither the indication fo...
All Cartilage No Stitch Type 1 Tympanoplasty – A Prospective Study
IntroductionAlthough temporalis fascia is the commonly used graft material for tympanoplasty, cartilage has become the material of choice in cases with eustachian tube dysfunction, bilateral disease, total or anterior pe...
Hearing Outcome in Canal Wall Down Mastoidectomy with Type III Tympanoplasty
ObjectivePreoperative and postoperative hearing results were compared in patients undergoing hearing reconstraction through canal wall down mastoidectomy with type III tympanoplasty method in our institute. Materials and...
A Novel Technique of Using Sponge as Post-Operative Nasal Packing
IntroductionIn an effort to find a comparable but less expensive nasal pack with the qualities of MerocelR,this study was aimed at comparing the clinical efficacy and patient comfort level, while simultaneously using Mer...