Comparative Trial of Phenobarbitone vs Phenytoin in Moderate and Severe Perinatal Asphyxia in Term Neonates
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 9
Abstract
A prospective, hospital-based open-label randomised trial was conducted with primary aim to compare the clinical seizure control after administration of either drug, Phenobarbitone or Phenytoin in term neonates with moderate or severe perinatal asphyxia. Secondary aim was to compare the neurodevelopmental outcomes at 3 months of age. Study participants included 120 term neonates (n=120) with perinatal asphyxia with clinically apparent seizures. Seizures were controlled in 8 out of 60 (13.33%) neonates who received phenytoin as compared to 43 out of 60 neonates (71.67 %) neonates who received phenobarbitone (p < 0.001). Phenobarbitone is more efficacious than Phenytoin in achieving clinical seizure control when used as first line anticonvulsant in term neonates with moderate or severe perinatal asphyxia. The early neurodevelopmental outcome at 3 months of age was similar when either of the drugs was used.
Authors and Affiliations
Dr Sanjana Sharma
Keywords
Related Articles
- EP ID EP516794
- DOI -
- Views 57
- Downloads 0
Abruptio placenta: A Retrospective Study on Aetiological Factors and Maternal Outcomes
Background: Abruptio placenta denotes separation of a normally implanted placenta after 20 weeks of gestation. This is a uniquely dangerous condition to both the mother and the foetus because of its potentially serious p...
Conventional Frontal Sinus Imaging In Identification Of Sex : Original Study In Population Of Udaipur City ,India .
Accurate sex prediction of human remains enables a more focused search of missing person’s files. The frontal sinus radiographs is useful in sex assessment of the bodies remain only with skull. The frontal sinuses are ab...
Centchroman - A Magical Pill or a Myth
MASTALGIA is a common symptom experienced by most of the females and most common complaint encountered in outpatient department. Many agents have been tried but till now ideal treatment still awaits. Centchroman (ormelox...
Role of Toti’s Procedure with Adjunctive Use of Mitomycin C in Management of Unsuccessful Dacryocystorhinostomy (DCR)
AIM: Prospective study to assess the success rate of repeat Dacryocystorhinostomy (DCR) surgery done with Mitomycin C (MMC) syringing on first postoperative day. METHOD: 43 patients qualifying inclusion criteria for repe...
Paroxysmal Nocturnal Haemoglobinuria (PNH): Rare Clinical Presentation of this Rare Disease
Paroxysmal Nocturnal Haemoglobinuria is a rare haematological disease causing acquired haemolytic anaemia. The clinical spectrum of the disease starts from anaemia (microcytic to macrocytic) to pancytopenia and aplastic...