Comparing Efficacy of Plain Bupivacaine, Bupivacaine with Fentanyl, and Bupivacaine with Dexmedetomidine Intrathecally in Lower Abdominal Surgical Procedures: A Double-Blind Randomized Control Study
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2018, Vol 6, Issue 2
Abstract
Introduction: The potentiating effect of short-acting lipophilic opioid fentanyl and a more selective α2 agonist dexmedetomidine is used to reduce the dose requirement of bupivacaine and its adverse effects and also to prolong analgesia. Aim: The aim of this study is to compare the effect of plain bupivacaine versus bupivacaine with fentanyl versus bupivacaine with dexmedetomidine administered intrathecally for lower abdominal surgeries. Methods: Group B (n = 30): Patients in this group received 3 ml of 0.5% hyperbaric bupivacaine of total volume of 3.0 ml. Group F (n = 30): Patients in this group received 2.5 ml of 0.5% hyperbaric bupivacaine + 25 μg (0.5 cc) of fentanyl to a total volume of 3.0 ml intrathecally. Group D (n = 30): Patients in this group received 2.5 ml of 0.5% hyperbaric bupivacaine + 5 μg (0.5cc) of preservative-free dexmedetomidine to a total volume of 3.0 ml intrathecally. Results: The time taken to achieve a sensory level of T10 and T6 was statistically insignificant among 3 groups. There was a statistically significant difference among three groups in the mean duration of motor block P < 0.0001. There was a statistically significant difference among three groups in the duration of time for demand analgesia P < 0.002. Conclusion: Intrathecal dexmedetomidine supplementation of spinal block seems to be a good alternative to intrathecal fentanyl since it produces prolonged sensory block and motor block.
Authors and Affiliations
R Srinivasan, Heber Anandan
Keywords
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