Comparing the Analgesic Efficacy of Parecoxib and Rofecoxib for Post-operative Analgesia Following Lower Abdominal Surgery
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2018, Vol 6, Issue 6
Abstract
Background: This study tested the hypothesis that an intravenous parecoxib 40 mg and deep intragluteal rofecoxib 40 mg will be effective for post-operative pain relief after hysterectomy and well tolerated. Materials and Methods: In this prospective, double-blinded, placebo-controlled study, we included 90 women posted for hysterectomy under spinal anesthesia. Patients were allocated into three groups in Group A (intravenous parecoxib 40 mg), Group B (deep intragluteal rofecoxib 25 mg), and Group C (2 mL normal saline). We administered studied drug preemptively, 15 min before the surgical incision. We measured pain on visual analog scale (VAS) and recorded observations at fixed intervals to investigate the duration of post-operative analgesia. We administered 100 mg tramadol as rescue analgesic once patient complained 25% pain relief on VAS. Results: A total of 90 patients were enrolled. All treatment groups had comparable demographics and baseline pain status. Overall, each rofecoxib dose was superior to each dose of parecoxib and parecoxib is superior to placebo for post-operative pain relief in patient who underwent hysterectomy. In our study, we observed that total duration of analgesia in Groups A-C was 3.42 ± 0.52 h, 5.23 ± 0.52 h, and 2.31 ± 0.23 h, respectively, and average duration of post-operative analgesia in Groups A-C was 1.21 ± 0.41 h, 3.04 ± 0.45 h, and 10 ± 0.18 min, respectively. All treatments were well tolerated. Conclusions: In this study, we found that deep intragluteal rofecoxib 25 mg is more effective than intravenous parecoxib 40 mg and placebo; similarly, intravenous parecoxib 40 mg is more effective than placebo for post-operative pain relief in patients who underwent hysterectomy. Rofecoxib extends post-operative analgesia up to 5 h, parecoxib up to 3 h without any adverse effects. We did not find comparable results with previous studies.
Authors and Affiliations
Veena Kachhwah, Neeraj Narang
Keywords
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