COMPARING THE EFFECT OF TWO METHODS OF ANESTHESIA INDUCTION ON CONSCIOUSNESS DURING ORTHOPEDIC SURGERY

Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2018, Vol 11, Issue 8

Abstract

Objectives: Consciousness during anesthesia is a non-reversible complication that may expose the patient to severe, long-term, emotional injuries and post-traumatic stress. Therefore, this study aimed to compare the effect of two methods of induction maintenance of anesthesia with thiopental sodium–remifentanil and propofol–alfentanil on consciousness during orthopedic surgery using a bispectral index (BIS) device.Methods: In this triple-blind clinical trial, 111 patients who underwent orthopedic surgery in Dezful Hospital (southwestern Iran) were investigated. Patients were randomly assigned into two groups: The intervention Group “A” received thiopental for the induction of and fentanyl for maintenance and intervention Group “B” received propofol and alfentanil. The patients underwent BIS monitoring before the end of surgery, and the BIS value was recorded. The Brice questionnaire was used to measure the consciousness. The data were analyzed using repeated Measure ANOVA test.Results: In the intervention Groups A and B, the mean BIS score was 63.71 and 60.62 in the first 5 min after surgery, reaching 65.25 and 67.73 60 min after surgery, respectively. The results of repeated measures ANOVA test showed that the mean BIS score was significantly different from the preoperative value (baseline) group during repeated measurements after surgery (5, 10, 15, 30, 40, and 60 min) (p<0.001). According to the Brice questionnaire, the prevalence of hearing loss during surgery showed a statistically significant difference between the two intervention Groups (A and B), and the incidence of hearing during surgery in intervention Group “B” was approximately 3 times higher than intervention Group “A” (odds ratio=3.22, 95% confidence interval: 1.32–7.79).Conclusion: The results indicate that none of the induction and maintenance pharmacologic methods have any superiority in terms of optimal depth of anesthesia in patients undergoing orthopedic surgery.

Authors and Affiliations

Farhad Nanaei, Sara Adarvishi, Maryam Dastoorpoor, Zohre Sekhavatpour

Keywords

Related Articles

The ORMULATION OF GLIMEPIRIDE AND ATORVASTATIN CALCIUM NANOPARTICLES BY 1 LIQUID ANTISOLVENT PRECIPITATION METHOD THROUGH DOUBLE STEP COMMINUTION 2 TECHNIQUE AND ITS EVALUATION

Objective: The present research is to formulate Glimepiride and Atorvastatin Calcium Nanoparticles for the type-2 diabetes mellitus for improvement of glucose tolerance associated with dyslipidemia formulated by liquid a...

ANTIOXIDANT ACTIVITY OF SOME NEWLY PREPARED SYMMETRICALLY AZO DYES DERIVED FROM SULFA DRUGS

Objective: Sulfa drugs (sulfonamides) were the first type of drugs largely medically used for preventive and chemotherapeutic agents against various types of diseases. To the date, much research has been directed toward...

HEMOGLOBIN LEVELS AFTER CONSUMING THE INITIAL PHASE OF ANTITUBERCULAR DRUGS

Objective: This study aims to determine the condition of the hemoglobin (Hb) level after the initial phase of antitubercular drug usage. Methods: This research method used a descriptive survey design with the accidental...

ANTI-ATHEROSCLEROTIC ACTIVITY OF ELAEOCARPUS GANITRUS ROXB. IN CHOLESTEROL-FED RABBITS

  Objectives: Atherosclerosis was experimentally induced in New Zealand white male rabbits by cholesterol feeding for 120 days for investigating effects of 70% ethanolic Elaeocarpus ganitrus seed extract (EEGS) against...

SOLUBILITY AND DISSOLUTION RATE ENHANCEMENT OF EZETIMIBE BY SOLID DISPERSION AND PELLETIZATION TECHNIQUES

Objective: In the present investigation, an attempt was made to improve the surface characters and solubility of the drug by solid dispersion and coating it on the non-pareil sugar beads as pellets. Methods: Ezetimibe s...

Download PDF file
  • EP ID EP567315
  • DOI 10.22159/ajpcr.2018.v11i8.25370
  • Views 146
  • Downloads 0

How To Cite

Farhad Nanaei, Sara Adarvishi, Maryam Dastoorpoor, Zohre Sekhavatpour (2018). COMPARING THE EFFECT OF TWO METHODS OF ANESTHESIA INDUCTION ON CONSCIOUSNESS DURING ORTHOPEDIC SURGERY. Asian Journal of Pharamceutical and Clinical Research, 11(8), 110-115. https://europub.co.uk/articles/-A-567315