Comparing the therapeutic action of octreotide, trimetazidine and their combination by pro-inflammatory and enzymatic changes in L-Arginine induced acute pancreatitis in male rats
Journal Title: Scholars Academic Journal of Pharmacy - Year 2017, Vol 6, Issue 12
Abstract
Acute pancreatitis continues to be associated with significant rates of mortality and morbidity, and therapeutic options are still very limited. Various theories have been suggested regarding the pathophysiology of acute pancreatitis, lot of research into different medical treatments for the treatment of acute pancreatitis, but it is not clear what benefits each treatment has, or indeed if any medical treatment is beneficial apart from supportive treatment. To clarify the potential therapeutic effect of octreotide, trimetazidine, and their combination in acute pancreatitis. Acute pancreatitis was induced by L-arginine and treated with octreotide subcutaneously,trimetazidineintraperitoneally and combination therapy by octreotide and trimetazidine. The rats were followed for 24 hours. At the 24th hour we determined serum levels of TNF-α, IL-1β, lipase, and amylase.TNF-α (p < 0.001), IL-1β (p < 0.001, lipase (p < 0.001), and amylase (p < 0.001) serum levels were significantly lower in combination group as compared with both octreotide and trimetazidine groups.Combination treatment markedly decreases biochemical and enzymatic changes in acute pancreatitis, thus ameliorate pancreatic injury in L-arginine induced acute pancreatitis. Keywords:acute, pancreatitis, arginine, octreotide, trimetazidine.
Authors and Affiliations
Sameer H. AL Rekabi, Hassan A. AL Aqooli, Muayed S. Salim
Keywords
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