Comparing the Therapeutic Effectiveness of N-acetylcysteine with the Combination of N-acetyl Cysteine and Cimetidine in Acute Acetaminophen Toxicity: A Double-Blinded Clinical Trial.
Journal Title: Electronic Physician - Year 2015, Vol 7, Issue 6
Abstract
N-acetylcysteine (NAC) has been used as a classic treatment for hepatotoxicity induced by N-acetyl-p-benzoquinone imine (NAPQI) as a metabolite of acetaminophen. However, cimetidine theoretically can reduce the production of toxic metabolites through the inhibition of cytochrome p450, and it recently was proposed as a complementary treatment for acetaminophen toxicity.
Authors and Affiliations
Mohsen Ebrahimi, Seyed Reza Mousavi, Alireza Ghassemi Toussi, Hamidreza Reihani, Farhad Bagherian
Keywords
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- EP ID EP128338
- DOI 10.14661/1310
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