Comparison Between Atorvastatin and Rosuvastatin on AntiThrombogenic Effect in Patients with Hyperlipidemia
Journal Title: Journal of Enam Meical College - Year 2018, Vol 8, Issue 3
Abstract
Background: Atorvastatin and rosuvastatin are two widely used HMG-CoA reductase inhibitors (statins). These are used as lipid-lowering drugs to reduce atherosclerosis-induced cardiovascular events. The benefcial effects of statins also involve some lipid-independent mechanisms which include modifcation of thrombus formation and degradation, alteration in inflammatory response, plaque stabilization and improvement of endothelial function. Objective: To compare antithrombogenic effect of atorvastatin and rosuvastatin in patients with hyperlipidemia. Materials and Methods: A prospective, open-labeled, interventional, randomized and single-center study was carried out in Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from March, 2016 to August, 2017 on 52 hyperlipidemic patients. After randomization patients were assigned to atorvastatin 10 mg or rosuvastatin 5 mg daily for 8 weeks. Blood was collected at baseline and after intervention to measure platelet count, prothrombin time (PT) and serum lipid profle. Results: The baseline characteristics of patients treated with atorvastatin and rosuvastatin were almost identical. The platelet count in atorvastatin group was reduced after intervention (2.30%, p=0.463) which was not signifcant but in rosuvastatin group platelet count reduced signifcantly (12.33%, p=0.021) after intervention. There was no statistically signifcant difference (p=0.187) between the two statin treated groups. PT was increased signifcantly after intervention in both atorvastatin group (31.44%, p<0.001) and in rosuvastatin group (31.93%, p=0.003), which was statistically signifcant. No signifcant difference was observed between the two groups (p=0.573). Both atorvastatin and rosuvastatin signifcantly improved serum lipid profle. Conclusion: The present study reveals that rosuvastatin reduced thrombogenesis more effectively than atorvastatin in hyperlipidemic patients.
Authors and Affiliations
Samia Haque Tonu, Jesmine Fauzia Dewan, Fahmida Hasnat, Begum Rudaba Jahan
Keywords
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- EP ID EP36313
- DOI https://doi.org/10.3329/jemc.v8i3.38365
- Views 267
- Downloads 0
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