Comparison between Roux-en-Y and Duodenal-jejunal Bypass on hyperglycemia improvements in SD rats
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 4
Abstract
Background：To treat Type 2 diabetes mellitus (T2DM), metabolic surgery which Roux-en-Y gastric bypass (RYGB) and Duodenal-jejunal bypass (DJB) are reported to induce significant improvements on hyperglycemia. In this study we compare the effects of these two surgeries and explore the possible underlying mechanism. Method：Sprague-Dawley (SD) rats were established of T2DM model and randomly assigned into three groups: the RYGB group, the DJB group and the Control group. Several indexes including body weight, food intake, fasting blood glucose and fasting glucagon-like peptide 1 (GLP-1) were measured during a postoperative 8-week period. Results：Our results revealed that both RYGB and DJB improved hyperglycemia efficiently along with elevated GLP-1 concentration compared to preoperative period. Moreover, RYGB demonstrated significantly better effects than DJB on decreasing blood glucose and induced a larger increase of GLP-1 levels (P<0.05). Conclusion：Both RYGB and DJB can significantly decrease blood glucose, RYGB being the more effective one. Postoprative increased GLP-1 levels in varying degrees could be a possible explanation as we seek further into their respective mechanisms.
Authors and Affiliations
Sen Wang, Wei Wei, Dong Tang, Nianyuan Ye, Gang Niu, Daorong Wang, Xiaofang Sun
Keywords
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- EP ID EP593455
- DOI 10.9790/0853-1604026773.
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