COMPARISON BETWEEN TAMSULOSIN AND SILODOSIN IN LOWER URETERIC STONE- A RANDOMISED CONTROLLED STUDY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 93
Abstract
BACKGROUND 70% of ureteral stones are located in the lower third of the ureter. Medical expulsive therapy (MET) using adrenergic antagonists has recently emerged as an alternative strategy for the initial management of small distal ureteral stones. We planned a study to compare the efficacy of silodosin 8 mg/ day with tamsulosin 0.4 mg/ day with respect to stone expulsion time and stone expulsion rate. MATERIALS AND METHODS A randomised controlled study was carried out on 70 cases having distal ureteric stones (DUS) of size ≤ 10 mm. All cases were above 20 years of age. 35 patients received single dose of tamsulosin 0.4 mg/ day and 35 patients received single dose of silodosin 8 mg/ day. Patients were followed by ultrasonography till stones were passed or upto 4 weeks after initiation of medical expulsive therapy. RESULTS 15 out of 27 cases in group tamsulosin and 23 out of 28 cases in group silodosin expelled the stones by the end of study. The mean time of expulsion in tamsulosin group was 19.1 ± 8.6 days, while silodosin group was 16.7 ± 6.8 days. The difference between tamsulosin and silodosin group did not reach statistical significance. The expulsion rate in tamsulosin group was 55.5% and silodosin group was 82.1%, which had statistical significance. The outcome of silodosin and tamsulosin was found to be not affected by the gender of patients. Silodosin is more effective in patients with distal ureteric calculi > 7 mm. CONCLUSION Silodosin was found to be more effectual than tamsulosin in terms of stone expulsion rate and stone expulsion time for the management of distal ureteric stones of size ≤ 10 mm.
Authors and Affiliations
Priyanka Priyanka, Ravikumar R Jadhav
Keywords
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- EP ID EP279588
- DOI 10.14260/jemds/2017/1465
- Views 100
- Downloads 0
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