COMPARISON OF 2 DIFFERENT DOSES OF ORAL PREGABALIN AS PREMEDICATION ON HAEMODYNAMIC PRESSOR RESPONSE DURING INTUBATION AND EXTUBATION IN MODIFIED RADICAL MASTECTOMY PATIENTS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 44
Abstract
BACKGROUND Intubation and extubation processes are associated with significant haemodynamic response, thus making adequate premedication a necessity. Our study compared 2 doses of oral pregabalin as premedication for blunting this haemodynamic response during intubation and extubation in patients undergoing modified radical mastectomy. MATERIALS AND METHODS A prospective observational study was carried out in adult female patients in the age group of 24-60 years undergoing modified radical mastectomy. A total of 90 patients were selected. Those who received oral placebo were placed in group I, those who received oral pregabalin 150 mg were placed in group II and those who received oral pregabalin 300 mg were placed in group III. The 3 groups were assessed for pre-operative sedation, haemodynamic changes from baseline to before and after intubation (0 min.), 5 min., 10 min. and before and after extubation (0 min.), 5 min., 10 min. Data analysis was done by ANOVA, independent T and Chi square test and statistical analysis was done using SPSS version 21.0. RESULTS Pre-operative sedation score was higher in both pregabalin groups. Statistically significant attenuation of mean arterial pressure and heart rate was seen in group II and III during and after intubation and extubation. No significant difference in blunting of haemodynamic response between 150 mg and 300 mg pregabalin premedication groups. CONCLUSION Pregabalin 150 mg and Pregabalin 300 mg as oral premedication were effective and safe in blunting of haemodynamic response to intubation and extubation without significant side effects in patients undergoing Modified Radical Mastectomy.
Authors and Affiliations
Nidhi Rani Gupta, Deepa George
Keywords
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- EP ID EP215557
- DOI 10.14260/Jemds/2017/741
- Views 93
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