Comparison of acute toxicities in patients of Head and Neck Cancer treated by 3D-CRT v/s IMRT
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 12
Abstract
Background: Radiotherapy plays a critical role in the management of many patients with head and neck cancer. In recent decades, the treatment for head and neck cancer has moved from two-dimensional radiotherapy to three-dimensional conformal radiotherapy (3D-CRT) and recently also to intensitymodulated radiotherapy (IMRT). In this study we aim to demonstrate difference of toxicity profile between 3D-CRT and IMRT in patients of head and neck cancer. Material and Methods: A total of 60 patients of head and neck cancer were randomly selected divided into two groups of 30 patients in each. Patients of group A received 3D-CRT and group B received IMRT. Patients of both arms received concurrent chemoradiation, were assessed weekly for local disease response & development of any acute skin or mucosal reactions. Xerostomia was assessed at the end of treatment, 1 month, 3 month and 6 month post radiotherapy. Xerostomia was also assessed and graded as per the CTCAE guidelines at 6 months follow up after treatment completion. Results: The median age in the 3D-CRT arm was 50.5 years with range of 21 to 70 years while the median age in IMRT arm was 38 years with range of 18 to 64 years. Male patients were more common in both arms than female patients (90% in 3D-CRT arm and 80% in IMRT arm). In 3D-CRT arm 83.3% patients and in IMRT arm 76.6% patients suffered from grade II acute skin reactions during treatment duration or at the end of treatment. In 3D-CRT arm 80% patients were with grade II and 10% patients were with grade III acute stomatitis while in IMRT arm 86.6% patients were with grade II and no patient was with grade III acute stomatitis during treatment or at end of treatment. There was no statistically significant difference in incidence and severity of both acute skin reaction and stomatitis during or at the end of treatment in both arms. At the end of treatment, 1 month, 3 month and 6 month post radiotherapy there was no significant www.jmscr.igmpublication.org Impact Factor (SJIF): 6.379 Index Copernicus Value: 79.54 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi.org/10.18535/jmscr/v6i12.130 Neha Rawat et al JMSCR Volume 06 Issue 12 December 2018 Page 807 JMSCR Vol||06||Issue||12||Page 806-816||December 2018 difference in incidence or RTOG grade of xerostomia between both the arms. While on assessing with CTCAE criteria there was significant difference in occurrence of grade III xerostomia at 6 months post radiotherapy between the two arms (63.3% in 3D-CRT arm v/s 30% in IMRT arm, p value = 0.009). There was no significant difference in the two arms in respect to treatment respone Conclusion: This study concluded that there was no significant difference in acute skin toxicity and stomatitis in head and neck cancer patients treated by either 3D-CRT or IMRT but there was significant difference in occurrence of higher grade xeostomia at 6 months in favor of IMRT. So, IMRT should be considered in treatment of head nand neck cancers to prevent higher grade xerostomia.
Authors and Affiliations
Dr H. S. Kumar
Keywords
Related Articles
- EP ID EP505314
- DOI -
- Views 66
- Downloads 0
An Observational Cross Sectional Study of Women with Pigmentation on Nape of Neck from a Tertiary Care Centre in North India
Background and Aims: Pigmentation of nape of neck is a fairly common disorder in Indian women but reports comprising a sizeable number of patients are lacking in the literature. We describe the clinicalepidemiological fe...
KAP on Malaria & HTN in Rural & Urban areas of Rangaraya Medical College, Kakinada
This study was done in the view to assess knowledge on malaria as an ancient disease and hypertension as a new epidemiological transition in rural and urban areas. After analyzing the results both the groups had knowledg...
A Prospective, Randomized Study to Compare Two Palliative Radiotherapy Schedules in Advanced Non-small Cell lung Cancer (Stage IV)
Introduction: Lung cancer is the most commonly diagnosed cancer worldwide and causes approximately 1–2 million deaths per year. Non-small cell lung cancer (NSCLC) accounts for at least 80% of all lung cancer cases, prese...
Knowledge Assessment of Appendicitis among Saudi Population
The aim of this study is to assess the knowledge, attitude and perception of Saudi population on appendicitis and appendectomy and to determine the level of awareness about appendicitis among Saudi Arabia; The population...
Non Infectious Causes of Stridor in Paediaric Age Group 0-12 Years in Tertiary Care Hospital
Introduction: Stridor is an Abnormal, Harsh, High Pitched Inspiratory Sound Produced by Turbulent Airflow Through Partially Obstructed Airway of the Laryngeal area of the Extrathoracic Trachea. Croup & Laaryngomalacia Ar...