Comparison of Alphapinene and Donpezil Effects on Passive Avoidance Memory in Adult Male Rats

Abstract

Background and Objectives: Alphapinene as one of the most important Components of essential oils, which has antioxidant and anti-cholinesterase activities. Oxidative stress directly affects the function of the brain and causes memory impairment. In this research, the effect of alphapinene on passive avoidance memory and oxidative stress, was investigated in comparison with donepezil.   Methods: In this study, 50 male Wistar rats were divided into 5 groups: control, sham (received alphapinene solvent), groups received 2 and 4mg/kg alphapinene, and group that received donepezil. The drugs were administered intraperitoneally for two weeks. At the end of the treatment, passive avoidance memory in animals, was assessed using the shuttle box test, level of malondialdehyde, total thiol concentration in blood, and hippocampal tissue as oxidative stress indices. One-way ANOVA and Tukey's post hoc tests, were used to determine the difference between the groups.   Results: Memory significantly increased in the group receiving donepezil (p<0.01), and in the groups that received alphapinene (doses, 2 and 4mg/kg), memory significantly increased compared to the control group (p<0.001). A significant increase was observed in the dose of 4mg/kg alphapinene compared to the donepezil group (p<0.001). The concentration of malondialdehyde in the hippocampus tissue significantly decreased in the group received the dose of 4mg/kg compared to the control group. Moreover, the total amount of hippocampal thiol showed a significant increase in the group receiving alphapinene (dose, 4mg/kg) compared to the control group (p<0.05).   Conclusion: The results of this study showed that alphapinene at dose of 4mg/kg had the highest effect on memory improvement even compared to the donepezil group and also decreased the oxidative stress indices due to its antioxidant property.

Authors and Affiliations

Kolsoum Nozari, Maryam Rafieirad

Keywords

Related Articles

الگوی اپیدمیولوژیکی انواع عفونت‌های قارچی جلدی در بیماران مراجعه‌کننده به بیمارستان رازی تهران، سال 1393

چکیده زمینه و هدف: عفونت‌های قارچی جلدی، جزء عفونت‌های شایع هستند که بافت‌های کراتینیزه (پوست، مو و ناخن) را گرفتار می‌کنند. درماتوفیت‌ها، مهم‌ترین و فراوان‌ترین عوامل قارچی جلدی محسوب می‌شوند. این مطالعه با هدف بررسی ا...

Comparison of the Effect of Three Combined Training Methods on Pain and Function in Patients with Patellofemoral Pain Syndrome

Background and Objectives: Patellofemoral pain syndrome is a common orthopedic disorder in knee joint, which causes pain and dysfunction. This study aimed to compare the effect of three combined training methods on pain...

ارتباط نمایه توده‌بدنی و دور کمر با عزت‌نفس در مردان جوان ایرانی

زمینه و هدف: امروزه، ملاک‌های پذیرش اجتماعی و موفقیت تغییر کرده که بر سلامت روان‌شناختی ازجمله عزت‌‌‌نفس افراد نیز تأثیر‌گذار است. از طرفی در دهه‌های اخیر، چاقی و اضافه وزن رو به افزایش بوده که می‌تواند تأثیرات زیادی بر...

Isolation, Molecular Identification, and Phylogenetic Analysis of Antimicrobial Agents Producing Actinomycetes in Farming Saline Soils of Qom City, (Iran)

Background and Objectives: Actinomycetes are Gram-positive and filamentous bacteria that are the major microorganism in soil. According to studies, three quarters of all known antibiotics are produced by actinomycetes. T...

The Antibacterial Effect of Methanol and Aqueous Extracts of Vaccinium arctostaphylos Fruit on Enteropathogenic Escherichia coli In Vitro

Background and Objectives: Enteropathogenic Escherichia coli strains cause a wide range of gastrointestinal infections, especially in developing countrirs. The aim of this study was to evaluate of the antibacterial effec...

Download PDF file
  • EP ID EP606838
  • DOI 10.29252/qums.13.4.1
  • Views 36
  • Downloads 0

How To Cite

Kolsoum Nozari, Maryam Rafieirad (2019). Comparison of Alphapinene and Donpezil Effects on Passive Avoidance Memory in Adult Male Rats. مجله علمی- پژوهشی دانشگاه علوم پزشکی قم, 13(4), 1-10. https://europub.co.uk/articles/-A-606838