Comparison of Anti-Platelet Efficacy of Four Different Marketed Formulations of Aspirin in Diabetic Patients
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 7
Abstract
Introduction: In India, Aspirin is marketed as multiple preparations for antiplatelet use and its drug release pattern is likely to affect efficacy. Objectives: The study compares anti-platelet efficacy of four preparations of aspirin against ADP-induced platelet aggregability and bleeding time (BT); and assesses correlation between steady state plasma concentration (CSS) and antiplatelet effect of daily 150mg Aspirin. Methods: This was a four armed, randomised, investigator-blinded, parallel-group, comparative study. Study was conducted in 121 subjects of Type 2 DM on oral anti-diabetics having one or more cardiovascular risk factors. Each subject was randomized to receive Plain aspirin, soluble, effervescent or enteric coated, for 15 days. Blood samples were taken at day 0 and day 15, two hours after dosing. Results: Total 121 subjects completed study (Plain 30, soluble 31, effervescent 30 and enteric coated 30) and the baseline characteristics were similar among all groups. All preparations inhibited platelet aggregation (Reduction from day 0 to day 15: plain-25.9%, soluble-23.9%, effervescent-23.5%, enteric coated-26.4%; p=0.89) and increased BT (Rise: plain-236.4%, soluble-236.1%, effervescent-229%, enteric coated-256.7%; p=0.87) to a similar extent. Salicylate CSS measured at day 15 was significantly higher in effervescent (23.75mg/L) as compared to enteric coated (19.73mg/L) and soluble (19.27mg/L). Plain aspirin produced salicylate CSS of 20.8mg/L. There was no significant correlation between salicylate CSS and antiplatelet activity for study population [r= -0.124, p= 0.179] or for individual groups. Conclusions: -All preparations produced comparable antiplatelet effect which did not correlate with steady state plasma salicylate concentration at daily dose of 150mg
Authors and Affiliations
Kanharam Narayan Patel
Keywords
Related Articles
- EP ID EP527633
- DOI -
- Views 46
- Downloads 0
A Cross Sectional Study amongst Paramedical and Nursing Students Regarding Cancer Awareness at a Tertiary Healthcare Institute in Northern India
The rising cancer incidence makes cancer prevention, early diagnosis and treatment a priority. Paramedical workers and Nurses in India are the most important and the largest section of the paramedical workforce. Awarenes...
Prevalence of Hypertension among Adults Attending A Tertiary Care Centre
Background: The burden of the chronic Non-Communicable Diseases (NCD), especially heart disease, stroke, hypertension, diabetes, cancer and chronic respiratory disease, is increasing in the low and the middle-income coun...
To Evaluate the Maternal & Fetal Complications and Outcomes in PostTerm Pregnancy: An Institutional Based Study
Background: A post-terms pregnancy is a pregnancy that lasts longer than 42 weeks. Because there are some very serious risks for both mother and baby, your healthcare provider will follow a post-term pregnancy closely. T...
Spectrum of Respiratory Pathogens, especially Filamentous Fungi causing Lower Respiratory Tract co-infections in cases of Pulmonary Tuberculosis
This study was conducted in a tertiary care hospital in Western India[1] To determine the spectrum and prevalence of pathogens in lower respiratory tract co-infections, in Pulmonary TB cases, with special emphasis on the...
Seroconversion and Prevalence of TTIs (Transfusion Transmissible Infections) among Blood Donors in Southern Part of India
Aims & Objectives: Effective screening of donors blood as per WHO guidelines and to assess the sero prevalence of HIV, HBsAg, HCV, Syphilis and Malaria among population in a locality in southern part of India based on th...