Comparison of Chelating Agents DMPS, DMSA and EDTA for the Diagnosis and Treatment of Chronic Metal Exposure
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2014, Vol 4, Issue 9
Abstract
Aims: Several chelating agents are presently used among environmental physicians to diagnose and treat a chronic metal overexposure. We evaluated and compared the binding capacity of the most common chelating agents DMPS (2, 3-dimercapto-1-propanesulfonic acid), DMSA (dimercaptosuccinic acid), also called Succimer) and EDTA (ethylene diamine tetraacetic acid) for the potentially toxic metals Antimony (Sb), Arsenic (As), Cadmium (Cd), Lead (Pb) and Mercury (Hg). Secondly, we evaluated how the nutrient elements Calcium (Ca), Copper (Cu) and Zinc (Zn) are affected by the chelating agents tested. Study Design: Through ICP-MS (Inductively Coupled Plasma Mass Spectroscopy) analysis of urine from environmentally burdened patients, we determined which chelating agent in oral or injectable form has the best potential to be used as a provocation test for the diagnosis of multiple metal over exposure, and which chelating agent is best used for the detoxification treatment of a single metal exposure. Place and Duration of Study: Micro Trace Minerals and Friedle Laboratories, Hersbruck/Regensburg, Germany, between January 2011 and February 2013. Methodology: Data utilized is based on urine samples from chronically exposed patients, male and female adults, received from chelation therapists. Acutely intoxicated patients were not included. Results: The intravenous application of DMPS is most suitable for the diagnosis and treatment of a single or multiple metal exposure, involving the metals Sb, As and Hg. Both EDTAs (NaCaEDTA and NaEDTA), administered intravenously, are the agents of choice for Cd, while Pb can be chelated using DMSA, DMPS, or the EDTAs. Both EDTAs have a strong Zn binding ability, but only NaEDTA is suitable for binding appreciable amounts of Ca. DMPS best binds Cu. Conclusion: The intravenous application of DMPS is most useful for the diagnosis of multiple metal overexposure. It is also the treatment of choice for Sb, As and Hg and has the strongest Cu binding ability of the chelators tested.
Authors and Affiliations
E. Blaurock-Busch, Y. M. Busch
Keywords
Related Articles
- EP ID EP348690
- DOI 10.9734/BJMMR/2014/6875
- Views 71
- Downloads 0
Adapted Technological Platform for Screening and Identifying Compounds Capable of In vivo Spinal Network-mediated Reflex Ejaculation in Non-anesthetized, Chronic Paraplegic Mice: Evidence of Clonidine-elicited Seminal Emission
Several drugs have been shown to facilitate locomotor rhythmogenesis and treadmill training after Spinal Cord Injury (SCI). Clonidine, an alpha-adrenoceptor agonist, is of particular interest given its well-known effects...
Search for Escherichia coli O157:H7 and Other Enterohaemorrhagic Escherichia coli in Diarrhoeal Cases in Abuja, Nigeria
Aims: To detect the sporadic involvement of shiga toxin producing Escherichia coli (STEC) O157:H7 or any other enterohaemorrhagic E. coli in gastro-intestinal (diarrhoeal) infections. Study Design: The study is a cross s...
Patients' Satisfaction after Orthognathic Surgery: A Systematic Review
Objective: The aim of the present study is to review data regarding patients' satisfaction after orthognatic surgery in a systematic approach. Methods and Materials: Electronic searching was done in Medline, EMBASE and C...
A Study of Cardiac Autonomic Neuropathy and Its Correlation with QTc Dispersion in Type-2 Diabetes Mellitus
Aims: To evaluate the presence of cardiac autonomic neuropathy in Type-2 Diabetes and to correlate autonomic dysfunction with QTc dispersion. Study Design: This was a hospital based cross-sectional study carried out in t...
Healing of Large Periapical Lesions by Non-surgical Approach - Case Reports
Introduction: Periapical lesions generally develop as a sequel to pulpal infection. When there is a large periapical tendency visible on the radiograph, clinicians tend to have a surgical approach towards treatment. Howe...