Comparison of clinical efficacy between laparoscopic total gastrectomy and proximal gastrectomy in the treatment of adenocarcinoma of esophagogastric junction
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 2
Abstract
<b>Objective</b> To compare the advantages and disadvantages of two different resection margins by observing the clinical efficacy of laparoscopic total gastrectomy (TG) and proximal gastrectomy(PG) for radical resection of adenocarcinoma of esophagogastric junction (AEJ). <b>Methods</b> A total of 90 patients with AEJ who were treated by Huai ‘an No.1 People ‘s Hospital from January 2020 to December 2021 were retrospectively reviewed. Patients were divided into PG group ( n=43) and TG group ( n=47) according to the surgical resection range. The general data, surgery related statistical indicators of the two groups were compared. <b>Results</b> The TG group had a longer operation time than the PG group, with significantly more intraoperative blood loss and a greater number of intraoperatively cleared lymph nodes than the PG group (P<0.05). There was no significant difference in terms of drainage volume of the abdominal drainage tubes in the 3day postoperative period, postoperative period to the drainage removal, the length of hospitalization, and postoperative complications between two groups (P>0.05). Postoperative levels of hemoglobin, albumin, and prealbumin were significant lower in TG group compared with those in PG group (P<0.05). The 1year overall survival rates for the PG group and TG group were 95.3% and 87.2%, respectively, and the difference was not statistically significant (P>0.05 ). <b>Conclusion</b> Compared with TG, PG is more conducive to the absorption of nutrients and the recovery of nutritional status after surgery, and it is also important to take optimal reconstruction methods to reduce reflux in patients.
Authors and Affiliations
DAI Dezhu, SHI Jin, SONG Xudong, DING Fan, TAO Guoquan
Efficacy and safety of oxaliplatin and capecitabine in combination with sintilimab as first-line treatment for HER2-negative advanced gastric cancer
"<b>Objective</b> To analyze the clinical efficacy and the occurrence of adverse events of the oxaliplatin and capecitabine (XELOX) combined with sintilimab as a first-line treatment in patients with human epidermal grow...
Effect of different administration methods of esketamine on postoperative pain after thoracoscopic lung surgery
Objective To investigate the effect of itravenous injection or infuson of esketamine on postoperative pain in patients undergoing thoracoscopic lung surgery. Methods A total of 90 patients who underwent elective thorac...
Current status and perspectives liquid biopsy in the whole-process management of tumor diagnosis and treatment
Effective detection methods play a pivotal role in early identification of cancer signal, thereby enhancing patient survival rates. Liquid biopsy, as a burgeoning non-invasive technology, provides comprehensive tumor inf...
Efficacy and safety of levocetirizine dihydrochloride in the treatment of pediatric asthmatic diseases
Objective To explore the safety and efficacy of levocetirizine dihydrochloride in the treatment of pediatric asthmatic diseases. Methods From March 2021 to December 2023, 200 pediatric patients with asthmatic diseases wh...
Research progress of the molecular mechanism between vitamin D and type 2 diabetes mellitus in children and adolescents
The incidence of type 2 diabetes mellitus (T2DM) is increasing globally. With the growing prevalence of obesity in childhood, the incidence of T2DM is also on the rise among children. Children with T2DM have worse persis...