Comparison of Clinical Findings, Histological Findings and Findings on DIF Examination in Autoimmune Vesiculobullous Disorders
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2015, Vol 3, Issue 2
Abstract
Autoimmune blistering disorders are characterized by presence of pathogenic autoantibodies directed against target antigens which are components of desmosome or adhesion complex of basement membrane zone. This leads to clevage at particular level and subsequent blister formation. The aim and objective of the work was to study the clinical, histopathological and immunofluorescence findings in autoimmune blistering disorders and to study correlation between them. The study was conducted in OPD of dermatology department. 38 patients presenting with clinical impression of autoimmune vesiculobullous disorder were included in the study. In all patients, detailed clinical history, examination & routine Investigations were carried out & findings were recorded. Biopsy for H & E and DIF was taken in all the cases. The maximum clinical, histopathological and immunological correlation was present in pemphigus vegetans, Herpes gestationis and paraneoplastic pemphigus (100% each), while the minimum correlation was seen in bullous pemphigoid 50%). In pemphigus vulgaris the correlation was present in 92% while in pemphigus foliaceous it was 66%. Out of 38 cases of autoimmune blistering disorder clinical, histopathological & immunological correlation was present in 21 cases (60%). It is preferable to correlate clinical, histopathological & immunofloroscence findings for more precise diagnosis & better patient management. Keywords: Autoimmune blistering disorders, autoantibodies, Biopsy.
Authors and Affiliations
Avanitaben Solanki, Neela Patel, Yogiraj Rathod, Jigna Barot
Keywords
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