COMPARISON OF CLINICO-PATHOLOGICAL FEATURES AND PROGNOSIS OF TRIPLE-NEGATIVE AND NON-TRIPLE-NEGATIVE FEMALE BREAST CANCER PATIENTS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 30
Abstract
BACKGROUND Triple-negative breast cancer patients have no expression of Oestrogen Receptor (ER), Progesterone Receptor (PR) and there is neither expression nor amplification of human epidermal growth factor receptor 2 in a tumour. But non-triple negative breast cancer patients have either oestrogen receptor or progesterone receptor or both positive with or without amplification of Human epidermal growth factor receptor 2 in a tumour. The purpose of this retrospective study is to compare and analyse the clinico-pathological features, recurrence, metastasis and prognosis of triple-negative breast cancer patients and non-triple negative breast cancer patients. MATERIALS AND METHODS A retrospective descriptive study for a total of 200 stage III female breast cancer patients (100 triple-negative patients and 100 non-triple-negative patients) were diagnosed and treated at the Department of Radiotherapy, T.D Medical College Hospital, Alappuzha from January 1st 2011 to December 31st 2011. The clinical features, recurrence, metastasis and prognosis of the two groups were compared. RESULTS The triple-negative breast cancer patients were characterised as younger age, higher histological grade, bigger tumour size, higher clinical stage at diagnosis, more recurrence and metastasis, lower 5-year disease free survival rate and 5-year overall survival rate. The lungs, liver and brain were the first three most common sites of metastases. CONCLUSION In our study, we found that triple-negative breast cancer was a distinct subgroup of breast cancer with particular clinico-pathologic behaviour. Compared with the non-triple-negative breast cancer, triple-negative breast cancer was characterised by more aggressive behaviour, metastasis tendency and lower disease-free survival and overall survival rate. This result suggested that characteristics like family history, premenopausal status, tumour size, histological grade of triple-negative breast cancer patients had more local relapse and metastases than that of in non-triple-negative breast cancer that was statistically significant.
Authors and Affiliations
Nonam Chellappan, Smitha G. Raj
Keywords
Related Articles
- EP ID EP538886
- DOI 10.14260/jemds/2018/770
- Views 82
- Downloads 0
A STUDY OF ASSOCIATION OF SEX HORMONES WITH INSULIN RESISTANCE AND OBESITY FOR DIABETES MELLITUS RISK IN ADULT WOMEN
BACKGROUND Sex hormones have a great impact on energy metabolism, body composition, vascular function and inflammatory responses and insulin resistance. Ovarian hormones influence insulin sensitivity across the lifespan...
A CLINICAL STUDY OF SUPPURATIVE KERATITIS
BACKGROUND Corneal blindness is a major problem in India. Corneal ulcer patients top the list among diseases causing corneal blindness and remain a liability to the family and community for the rest of their lives. Hence...
ANALYSIS OF SEMEN STUDIES OF 200 MEN ATTENDING AN INFERTILITY CLINIC IN A TERTIARY CARE CENTRE
BACKGROUND Various characteristics of the male population reporting for infertility evaluation were seen in their semen studies. Aim- To study the various variables of the semen analysis data. MATERIALS AND METHODS Prosp...
CLINICAL SPECTRUM OF OPPORTUNISTIC INFECTIONS IN HIV POSITIVE PATIENTS
The human immunodeficiency virus (HIV) infection leading to Acquired Immunodeficiency Syndrome (AIDS) causes progressive decline in immunological response in people living with HIV/AIDS, making them susceptible to...
DISSOCIATIVE AMNESIA WITH DISSOCIATIVE FUGUE- A CASE REPORT WITH 1-YEAR FOLLOWUP
PRESENTATION OF CASE A 53-year old man had gone missing for six months and therefore was evaluated to ascertain psychiatric fitness before joining work. On workup, he was found to be educated upto Class 9, a regular empl...