Comparison of Cyclosporine with Systemic Corticosteroid in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis - A Pilot Study
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2018, Vol 5, Issue 11
Abstract
Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening dermatological emergencies. Many immunosuppressive modalities have been tried with variable results. Aims: This study aims to determine the efficacy of cyclosporine in cases of SJS and TEN and compare the efficacy with systemic corticosteroid in the same condition. Materials and Methods: The study was conducted at a tertiary hospital from January 2015 to December 2017. SCORTEN was assessed at the time of admission. Total body surface area assessment was like any burn patients. Cyclosporine was administered in the dose of 4 mg/kg body weight in two divided dosage for 7 days and then tapered over another 7 days. Data were compared to a similar control series of SJS/TEN patients, managed by systemic steroids in the same time period. Results: A total of 19 consecutive patients with a mean age of 32.09 and standard deviation ([SD] 16.17) were enrolled into cyclosporine group, which were compared to 19 patients with a mean age of 27.87 (SD 13.97) years in the corticosteroid group. The mean duration of reepithelialization was 14.54 (SD 4.08) and 23 days (SD 6.68) in cyclosporine and corticosteroid group, respectively. Mean hospital stay was 18.09 (SD 5.02) and 26 (SD 6.48) days in cyclosporine and corticosteroid group, respectively. Total mortality was 9. A total of 3 patients died in the cyclosporine group with 2 male and 1 female, compared to 6 deaths occured in corticosteroid group 4 female, 2 male. Conclusion: This study definitely suggests that cyclosporine has encouraging role in the management of uncomplicated cases of SJS, SJS-TEN overlap, or TEN, but randomized control trails are needed for further confirmation.
Authors and Affiliations
Singh Kumar Santosh, Ali Mohammad, Lalit Mohan, Anil Kumar Gupta, Dr Sushantika, Naveen Kumar
Keywords
Related Articles
- EP ID EP477274
- DOI -
- Views 109
- Downloads 0
Predictors of Visual Acuity in Traumatic Cataract
Aim: Traumatic cataract has many challenges. Strategic management to achieve the expected visual outcome is necessary. This study evaluates visual outcome and probable predictors of visual prognosis in traumatic cataract...
Serum Sodium Levels and Probability of Recurrent Febrile Convulsions
Introduction: Febrile seizures are seizures that occur between the age of 6 and 60 months with a temperature of 38°C or higher, that are not the result of the central nervous system infection or any metabolic imbalance,...
Evaluation of the Efficacy of Intrathecal Fentanyl Versus Intrathecal Nalbuphine as Adjuvants to 0.75% Ropivacaine for Post-operative Pain Relief in Cesarean Section: A Double-blind Randomized Comparative Study
Abstract Background: Spinal anesthesia is safe, simple to perform, and also has many advantages such as intense analgesia and awake mother to permit bondage between mother and the newborn. Nalbuphine is a mixed agonist–a...
Study of Functional and Radiological Outcome of Midshaft Clavicle Fractures Managed Operatively With Plating
Introduction: Clavicle is one of the commonly fractured bones. Shortcomings of conservative treatment are non-cosmetic bump in addition to non-union in few cases. Shortcomings of operative treatment are hypertrophic scar...
Comparative Study of Akin Staging and Pediatric - Risk, Injury, Failure, Loss, End-stage Kidney Classification in Identifying Acute Kidney Injury in Critically Ill Children
Introduction: Acute kidney injury (AKI) is a common comorbidity in critically ill children, associated with an increased risk of morbidity and mortality. Modern definitions of AKI based on changes in serum creatinine (Cr...