Comparison of CYFRA 21-1, CEA, CA 19-9 and CA 72-4 levels in gastric cancer
Journal Title: Dicle Tıp Dergisi - Year 2013, Vol 40, Issue 2
Abstract
Objective: Gastric cancer is the fourth most common malignancy, and the second most common cause of cancer mortality worldwide. The aim of this study was to investigate the role of biomarkers CYFRA 21-1, CA 19-9, CEA, CA72.4 at diagnosis and throughout the follow-up in patients with gastric cancer. Methods: 30 patients with gastric cancer diagnosed and 31 healthy people as a control group were included in this study. According to the TNM staging system, there were 16 patients with stage II and 14 patients with stage III in the group of patients with gastric cancer. CEA, CA 19-9, CA 72-4 and CYFRA 21-1 levels were studied by elektrochemiluminescence immunasay (ECLIA) method in the Cobas e 601 instrument. Results: Statistically the level of CA 72-4, CA 19-9, CEA and CYFRA 21-1 gastric cancer groups was found significant high accaording to healthy control group (p<0.01). Statistically compared with II stage patient group, the level of CA 19-9, CEA and CYFRA 21-1 of III stage patient group was found significant high (p<0.01). The diagnostic cut-off, sensitivity and specificity for CEA were 4.15 ng/ mL, 46 % and 96%, respectively; for CA 19-9 were 24.50 U/mL, 17 % and 96 %; for CA 72-4 were 2.46 U/mL, 53 % and 96% and for CYFRA 21-1 were 3.36 ng/mL, 46% and 100%. Conclusion: Our study demonstrates that the association of biomarkers CYFRA 21-1, CEA, and CA72.4 provides a valuable contribution in the follow-up of gastric cancer patients. Key words: Gastric cancer, tumor markers, CYFRA 21-1
Authors and Affiliations
Gökhan Çakırca, Cemal Polat, Ali İnal, Mehmet Küçüköner, Nuriye Mete, Fatma Işık
Keywords
Related Articles
- EP ID EP98623
- DOI 10.5798/diclemedj.0921.2013.02.0259
- Views 141
- Downloads 0
Weakness of unilateral lower limb’s proximal muscle; diabetic amyotrophy coexisting with lumbar discopathy: Case report and review of the literature
Diabetic amyotrophy is a relatively infrequent complication of diabetes mellitus is most often characterized by weakness of unilateral lower limb and pain. Clinical differentiation from lumbar disc herniation may be dif...
Primary amyloidosis of urinary bladder
Primary amyloidosis of the bladder is a rare pathological condition, which the etiology is unknown. The signs and symptoms suggests bladder tumor. In some patients, lower urinary tract symptoms such as lower abdominal...
İnfluenza virüsü (H1N1)’ne sekonder gelişen miyokardit olgusu
İnfluenza, sağlıklı çocuklarda genellikle kendi kendini sınırlayan, akut ve komplikasyonsuz bir hastalık olsa da nadiren ciddi hastalık tablosu oluşturup ölüme neden olabilir. Enfeksiyonun en sık komplikasyonu pnömoni ol...
Relationship between Neutrophil-to-Lymphocyte Ratio and Prognosis in Patients with Deep Neck Space Infection
Objective: The aim of this study was to demonstrate if there is any relation between the neutrophil-to-lymphocyte ratio and prognosis in patients with deep neck space infections Methods: One hundred eight patients who...
The identification of Candida species isolated from clinical specimens of immunocompromised patients with PCR and determination of antifungal resistance genes with RFLP and sequencing analysis
Objectives: The aim of this study is to investigate PCR technique and antifungal resistance genes with RFLP and sequencing analysis in Candida species isolated from clinical specimens of immune-compromised patients....