Comparison of Dexmedetomidine Infusion with Saline Placebo for Smooth Extubation in Hypertensive Patient for Major Surgery
Journal Title: International Journal of Innovative Research in Medical Science - Year 2017, Vol 2, Issue 8
Abstract
Background: The objective of this study was to compare the effects of intravenous dexmedetomidine and saline placebo on recovery characteristics in hypertensive patients. Methods: In a double blinded trial, forty patients detected to have hypertension were randomly allocated to receive either dexmedetomidine 0.5 μg /kg/h (Group D) (n = 20) or saline placebo (Group N) (n = 20) intravenously. Level of sedation and coughing was evaluated using observer assessment sedation score (OSSA). The time for tracheal extubation and emergence from anaesthesia were recorded. Results: The degree of sedation and airway reflexes and circulatory responses at suction and extubation were analyzed and was found to be better in Group D (P=0.013). Smoothness of extubation assessed as coughing on endotracheal tube was comparable in both the groups (P=0.527). There was highly statistically significant increase in time for tracheal extubation and emergence from anaesthesia in group D (P<0.001). Conclusion: These findings suggest that an infusion of dexmedetomidine in hypertensive patients attenuates airway reflexes during surgery and at extubation, thus provided stable safe and reliable extubation
Authors and Affiliations
Sheeba Franklin
Keywords
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