COMPARISON OF DEXMEDETOMIDINE WITH FENTANYL IN ATTENUATION OF PRESSOR RESPONSE TO LARYNGOSCOPY AND INTUBATION
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 54
Abstract
BACKGROUND Direct laryngoscopy and endotracheal intubation elicits a haemodynamic response associated with increased heart rate and blood pressure. The aim of the study is to compare the efficacy of intravenous dexmedetomidine and fentanyl in attenuation of stress response to laryngoscopy and intubation. MATERIALS AND METHODS Study was carried out on 60 patients belonging to ASA grade I & II, aged 15 to 65 years including either gender scheduled for elective surgical procedures under general anaesthesia in Osmania General Hospital. Patients were randomly divided into two groups of 30 each. Group D received 0.6g/kg dexmedetomidine and Group F received 2 g/kg fentanyl diluted in 10 mL normal saline 10 minutes before laryngoscopy and intubation. Anaesthesia was standardised in both groups and vital parameters heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure were recorded preoperatively, during intubation and up to 10 minutes after intubation. RESULTS The groups were well matched for their demographic data. It was observed that increase in heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure after intubation was highly significant in fentanyl group as compared to dexmedetomidine. There was a statistically significant difference (P <0.05) between dexmedetomidine and fentanyl groups in heart rate, systolic, diastolic blood pressure and mean arterial pressure at all time points after tracheal intubation. CONCLUSION Both the drugs attenuated the pressor response. Among the two drugs administered dexmedetomidine 0.6 µg/kg provides reliable and effective attenuation of pressor response to laryngoscopy and tracheal intubation when compared to fentanyl in a dose of 2 µg/kg.
Authors and Affiliations
Sumathi Natta, Preethi Dasari, Deepraj Singh B
Keywords
Related Articles
- EP ID EP220419
- DOI 10.18410/jebmh/2017/652
- Views 96
- Downloads 0
EUSTACHIAN TUBE: ITS FUNCTIONS AND DYSFUNCTIONS IN RELATION TO THE PATHOGENESIS OF MIDDLE EAR
Knowledge of developmental anatomy and physiology of Eustachian tube provides evidence that most infants and young children will have fewer episodes of otitis media as the age advances, thus aggressive measures are not w...
BLOOD PRESSURE RESPONSE TO COLD PRESSOR TEST AMONG CHILDREN OF HYPERTENSIVE AND NORMOTENSIVE PARENTS
BACKGROUND Hypertension is one of the leading causes of premature death worldwide and the problem is growing. It is a risk factor for coronary heart disease and the single most important risk factor for stroke. Inheritan...
MORPHOMETRIC STUDY OF THE ARTICULAR SURFACES OF BONES FORMING THE TIBIO-FIBULAR MORTISE IN SOUTH INDIAN POPULATION
Talocrural joint is major weight bearing joint of the body, since human is the only known obligate bipedals. Therefore the body weight is transmitted to the ground through the two lower limbs. So some great features have...
CLINICAL STUDY OF ACUTE SUBDURAL HAEMATOMA
BACKGROUND Acute subdural haematoma is the most common type of traumatic intracranial haematoma accounting for 24% cases of severe head injuries and carries highest mortality. This study is designed to assess clinical ch...
COMPARISON OF POSTOP SIA IN MSICS WITH STRAIGHT INCISION VERSUS FROWN INCISION
BACKGROUND Surgically-Induced Astigmatism (SIA) is one of the commonest causes of poor postoperative vision even after uneventful cataract surgery. Recent advances have led to a newer concept of “refractive cataract surg...