Comparison of Different Doses of Fentanyl for Attenuating Stress Response and Side Effects of Etomidate during Induction and Intubation: A Randomized Control Study
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 1
Abstract
Introduction: Etomidate is a rapidly acting induction agent and it has little effect on cardiovascular system and it allows rapid recovery from anaesthesia but associated with side effects. Pre-treatment with narcotic analgesics usually Fentanyl can decrease the incidence of pain on injection and myoclonus during induction of anaesthesia with Etomidate and also attenuates the stress response to endotracheal intubation. Objective: The objective of this study is to evaluate the efficacy of different doses of Inj.Fentanyl for attenuating the stress response and side effects of Etomidate during induction and intubation. Methods and Methods: In this prospective randomised study 60 patients undergoing elective surgeries under general anaesthesia included in the study and they were randomly allocated into two groups of 30 each. Group I received 2 μ/kg of Fentanyl and Group II received 5 μ/kg of fentanyl. After 5 minutes of administration of either one of these all patients were induced with etomidate at a dose of 0.3 mg/kg. The parameters monitored are pain on injection, myoclonus, apnoea, heart rate, systemic blood pressure, post operative nausea and vomiting. Results: We found that the hemodynamic response and side effects were lower in group II with increasing dose of Fentanyl. But at the same time there was increasing incidence of post operative nausea & vomiting and apnoea in group II. Conclusion: We concluded that at a dose of 5 μg/kg of fentanyl, there is reduction of side effects of etomidate and also there is attenuation of hemodynamic response to intubation in patients undergoing elective surgeries under general anaesthesia with etomidate as induction agent.
Authors and Affiliations
S Vijayaragavan
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