COMPARISON OF DOSIMETRIC CONSTRAINTS BETWEEN CONFORMATIONAL RADIOTHERAPY AND INTENSITY MODULATED RADIOTHERAPY, ON ORGANS AT RISK IN TREATMENT OF BRAIN TUMORS
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2019, Vol 6, Issue 1
Abstract
Over the past two decades, radiation delivery has evolved from conventional external beam two-dimensional RT (2DRT) to three dimensional conformal RT (3DCRT). In a further advance, intensity-modulated RT (IMRT) uses computed tomography-based planning and delivery of radiation, aided by computerized optimization of the intensities of multiple beams. This improves the ability to tightly conform the treatment volume to concave tumor shapes, while minimizing doses to organs at risk (OAR), it can provide significantly better tumor target coverage and sparing of sensitive normal tissue compared with 3DCRT. Intensity-modulated radiation therapy (IMRT) using dynamic or static multileaf collimators delivers highly conformal dose while sparing the surrounding normal structures. Using a conventional multileaf collimator can be made in a “dynamic” or “static” form. The dosevolume- histogram (DVH) is a common tool to express the dose that is delivered to targets and organs-at risk (OAR). A DVH contains information about the doses delivered to partial volumes (either absolute or relative) of targets or OARs. However, DVHs do not provide spatial information such as the location of the high- and low-dose regions (“hot” and “cold” spots) inside the volume of interest (VOI). Our big interest of our study is to compare target dose distribution and dose to normal tissue for brain tumors using intensity modulated and three dimensional conformal radiotherapy.
Authors and Affiliations
Dr. Ghammad Sanae
Keywords
Related Articles
- EP ID EP672499
- DOI -
- Views 128
- Downloads 0
A CITYWIDE TRAUMA EXPERIENCE IN NIGERIA: THE WAY FORWARDS
Trauma is increasing in developing countries following technological and vehicular transportation advancement with attendant heightening of morbidity and mortality. As part of quest to reduce agony of trauma to barest mi...
PREGNANCY COMPLICATED BY SNAKE BITE: A CASE REPORT
Snake bite though rare among pregnant women; however, have serious consequences both for the mother and fetus. Little is known about the maternal and fetal outcome following snake bite of a pregnant woman. This case repo...
CHIKUNGUNYA VIRUS INFECTION EVALUATION USING RAPID DIAGNOSTIC TESTS (RDTS) BASED ON ANTI-CHIKUNGUNYA IGM/IGG
Chikungunya virus (CHIKV) is a single-stranded RNA alphavirus. Recently, CHIKV began an unprecedented global expansion. Thus, it is necessary to develop commercial rapid diagnostic kits for CHIKV infection. We assessed t...
CORRELATION BETWEEN EXPRESSION OF BCL-2, BAX & P53 AND HISTOLOGICAL ALTERATIONS IN BREAST CANCER OF EGYPTIAN PATIENTS
In Egypt, breast cancer represents approximately 33% of all female cancers and 29% of cancer cases treated at the National Cancer Institute. The present work aimed to determine the differences between normal breast tissu...
THE EFFECT OF DIABETES MELLITUS TYPE I AND TYPE II ON WHITE BLOOD CELLS
Diabetes mellitus (DM) is a growing global public health problem. The purpose of this study was to evaluate the elevated white blood cell (WBC) count associated with diabetes. Therefore, we investigated the relationship...