Comparison of Emulsification and Ionic Gelation Method of Preparation of Mucoadhesive Microsphere

Journal Title: The Pharma Innovation - Year 2012, Vol 1, Issue 5

Abstract

The purpose of this study was to prepare and characterize microspheres loaded by Aceclofenac. To achieve this goal Chitosan and Sodium alginate microspheres loaded by Aceclofenac were prepared by emulsification and ionic gelation methods. Morphology, size, encapsulation efficiency and drug release from these microspheres were evaluated. Microscopic evaluation of microspheres showed that microspheres were spherical in shape. The size analysis results indicated that size range varied from 1 to 13 µm. Encapsulation efficiency of microspheres was increased by increasing drug to polymer ratio. Drug release was found to be Zero order. In conclusion, microspheres loaded with Aceclofenac were prepared that could be used for control delivery of Aceclofenac.

Authors and Affiliations

Swati Chaturvedi, P. K. Sharma , Sharad Visht , Shanu Tyagi

Keywords

Related Articles

Comparison of Emulsification and Ionic Gelation Method of Preparation of Mucoadhesive Microsphere

The purpose of this study was to prepare and characterize microspheres loaded by Aceclofenac. To achieve this goal Chitosan and Sodium alginate microspheres loaded by Aceclofenac were prepared by emulsification and ionic...

Polysaccharides and Natural Gums for Colon Drug Delivery

The site‐specific delivery of the drugs to the target sites has the potential to reduce the side effects and improved the pharmacological response. The colon drug targeting is also exploited for systemic delivery of acti...

Resealed Erythrocytes as a Carrier for Drug Targeting: A Review

Erythrocytes have been the most interesting carrier and have found to possess great potential in drug targeting. Resealed erythrocytes are gaining more popularity because of their ability to circulate throughout the body...

Antibiotic Prescription and Cost Patterns In An Intensive Care Unit: A Review of Literature

Patients admitted to the ICU are seriously ill and often suffer from chronic critical illnesses. Antibiotics are the most frequently prescribed drugs among hospitalized patients especially in intensive care and surgical...

Methods Development of Fluconazole Tablets (400 Mg)

A spectrophotometric method has been developed for the determination of fluconazole in bulk, tablet and suspension dosage forms. Solution of fluconazole in methanol glacial acetic acid solution shows maximum absorbance a...

Download PDF file
  • EP ID EP145704
  • DOI -
  • Views 121
  • Downloads 0

How To Cite

Swati Chaturvedi, P. K. Sharma, Sharad Visht, Shanu Tyagi (2012). Comparison of Emulsification and Ionic Gelation Method of Preparation of Mucoadhesive Microsphere. The Pharma Innovation, 1(5), 1-10. https://europub.co.uk/articles/-A-145704