Comparison of Endometrial Changes in Uterine Leiomyoma and Adenomyosis of Uterus with Correlation of Serum Estradiol and Progesterone Levels
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 11
Abstract
Abstract Background: Both leiomyoma and adenomyosis are commonly encountered gynecological pathologies. It is a well-established fact that hyperestrogenic state is associated with growth of leiomyoma but the exact etiology of adenomyosis is unknown. Adenomyosis is also thought to be an estrogen dependent disease. Similarly, it has also been found that progesterone receptors are increased in leiomyomas whereasa decreased responsiveness of the ectopic endometrium to progesterone has been found in adenomyosis. Thus these two hormones are intricately related to leiomyoma and adenomyosis. Aims: The aim of this study is to note the changes in endometrium that can be found in the respective cases of uterine leiomyoma and adenomyosis of uterus. Materials and Methods: The study was conducted over a period of 12 months included 73 cases of leiomyoma and 73 cases of adenomyosis. Serum estradiol and progesterone levels of all the patients were measured by chemiluminescence immunoassay. Results: In leiomyoma, inactive basal endometrium was the most common finding 36/73 (49.31%) and in adenomyosis simple hyperplasia of endometrium was found in majority 30/73 (41.09%). However, both estradiol and progesterone levels in leiomyoma and adenomyosis were mostly within the normal range. Conclusion: Though both leiomyoma and adenomyosis are associated with a hyper estrogenic state, leiomyoma had inactive basal endometrium while adenomyosis had hyperplasia. Adenomyosis was also found to be associated with other pathologies like endometrial carcinoma, complex hyperplasia. Hence, in adenomyosis other associated pathologies should be looked for. .
Authors and Affiliations
Debosmita Bhattacharyya
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