Comparison of ER, PR & HER2/neu(C-erb B2) reactivity pattern with various histomorphological patterns in patients with breast cancer
Journal Title: IP Journal of Diagnostic Pathology and Oncology - Year 2018, Vol 3, Issue 4
Abstract
Introduction Globally carcinoma breast is the leading cause of cancer death in women Prognosis of such patients is related to a variety of Histomorphological features which includes Histological grade type tumor size and lymph node metastases Estrogen and progesterone receptors ER PR and more recently HER2neu have with increasing importance influenced the management of the malignancyMaterials and Methods This study was carried out at tertiary care hospital which included 70 cases of breast cancer that we have reported at our department during a period from June 2012 to June 2014Specimens were fixed overnight in 10 Neutral buffered formalin and processed as routine for HE staining Representative sections with tumour with adjacent normal breast tissue internal control were taken on PolyLLysine coated slides and proceed for antigen retrieval HRP Polymerization steps and than processed for ER PR and HER2neu immunohistochemical staining with respective antibodyObservation and Results Maximum No Of cases were in age group 5th and 6th decade with Invasive ductal carcinoma was predominately observed followed by invasive lobular carcinoma Among 70 cases 25 cases 3571 showing ERPR HER 2 pattern which is predominant pattern in this study While 23 cases 3285 showing Tripple negative patternConclusion most important cost effective prognostic markers are estrogen receptor status progesterone receptor status and HER2neu status Correlation of these marker status with clinical parameters helps in predicting the future treatment modalities and disease free survival for the patient in developing countriesKeywords EREstrogen receptor PRProgesteron recptor Immunohistochemistry
Authors and Affiliations
Atul Shrivastava, Alpesh M. Maru, Tejas Chokshi, A. S. Agnihotri
Keywords
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- EP ID EP482770
- DOI 10.18231/2581-3706.2018.0050
- Views 94
- Downloads 0
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