Comparison of expression of selected proteins in the cells of intestinal and diffuse type gastric cancer – immunohistochemical analysis
Journal Title: Progress in Health Sciences - Year 2014, Vol 4, Issue 1
Abstract
Introduction: Despite the progress in gaining knowledge about carcinogenesis, it is still unclear what processes are directly responsible for the differentiation of gastric cancer into its intestinal or diffuse form. Dividing of these two forms is based on one of the oldest, yet still commonly used classifications – the classification of Lauren. There are many factors that may influence the formation of gastric tumors of various aggressiveness. Purpose: To evaluate the expression of proteins: fragile histidine triad (FHIT), E-cadherin, α-catenin, γ-catenin, cathepsin B, epidermal growth factor (EGF), HER-2, MMP-9, MCM-2, Bak, Bax, BID, Bcl-XL, p53, FasL, Bcl-2, caspase-8, procaspase-3 in gastric cancer cells, depending on the type of tumor by Lauren classification. Materials and methods: Study group consisted of 91 patients treated surgically for gastric cancer in the Second Department of General and Gastroenterological Surgery, Medical University of Bialystok in years between 2000 and 2006. Results: It is shown, that the expression of E-cadherin was significantly higher in the Lauren I gastric cancer cells than in Lauren II. In case of caspase-8 there has been significantly less frequent expression of this protein in Lauren I gastric cancer cells compared to Lauren II. The authors describe no statistically significant differences in the expression of other proteins taken into consideration. Conclusions: These results suggest the role of adhesion and apoptosis-related proteins in the development of two different types of gastric cancer according to Lauren’s classification.
Authors and Affiliations
M Gryko, A Prycznicz, T Dawidziuk, J Zińczuk, D Cepowicz, Z Kamocki, B Kędra, K Guzińska-Ustymowicz
Keywords
Related Articles
- EP ID EP75232
- DOI -
- Views 79
- Downloads 0
Learning styles and Locus of control in undergraduate medical, nursing and physiotherapy students: a comparative study
Introduction: Locus of control is a personality variable which influences expectancies that people have in relation to everyday outcomes. The orientation on the Locus of control can be internal or external. People with i...
The forgotten stories on patients who made history
Basic books on medical eponyms, history of medicine or medical dictionaries, describe usually the historical contribution of scientists and physicians. It is impossible to ignore the role of patients in some medical disc...
Keeping going, why osteopaths of retiring age still practice – a qualitative study
Introduction: Osteopathy is a manual healthcare practice which has its roots in alternative and complementary medicine. The last thirty years have seen significant political, educational and professional developments in...
On the issue of determination of the threshold ratios of narcotic drugs as features of traffic offenses and misdemeanors
The issue presented in this article is the problem of specificity of the features which constitute the prohibited acts whose definitions contain the term condition under the influence and the term condition after consump...
Coaching as a method for potentially reducing the risk of burnout in medical professionals
In their daily work, medical professionals often encounter emotionally and mentally challenging situations, such as sudden health deterioration or death of their patients. The concern to ensure the highest possible level...