Comparison of Extremely Drug Resistant Tuberculosis Versus Multidrug Resistant-Tuberculosis Patients Attending a Tertiary Care Center Delivering DOTs Plus Regime
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 3
Abstract
Background: Extremely drug resistant tuberculosis (XDR-TB) is a very difficult clinical problem currently faced by many of the developing and some of the developed nations of the world. It is associated with considerable morbidity and mortality. Less effective medications with frequent side effects makes the scenario all the more worse. In Kerala, the Revised National Tuberculosis Control Programme (RNTCP) has implemented the Programmatic management of drug resistant tuberculosis by providing standardized treatment for XDR-TB under the CAT-V regime and CAT-IV regime for MDR TB patients under the DOTs plus strategy which is a nationwide TB control programme currently existent throughout the whole of India. Aim: To compare the clinical profile and mortality trends of XDR versus MDR TB patients attending a tertiary care setting. Methodology: All patients who got enrolled for the CAT-IV & CAT-V regime as per RNTCP for MDR & XDR-TB respectively at the DOTs plus centre, Kozhikode from June 2012 till the second quarter of June 2014 were included for the descriptive analysis. Results: There were 4.14 & 0.22 cases per lakh population of MDR/XDR-TB cases reporting to this centre during this period. Majority were males, smokers among both the groups. 38.8% of MDR TB patients and 45% of XDR TB patients were diabetics. 50-60% mortality was observed for XDR TB patients during this period as compared to 16 -25 % mortality in MDR TB patients. Conclusion: This study showed that XDR TB as compared to MDR TB was more difficult to manage and had more than double mortality rates. Hence stress should be more on early diagnosis and proper management of drug sensitive cases and MDR-TB cases and reducing incidence of XDR TB cases.
Authors and Affiliations
Sunny George
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