COMPARISON OF HYPERFRACTIONATION AND CONVENTIONAL METHOD OF RADIOTHERAPY IN HEAD AND NECK CANCERS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 84
Abstract
BACKGROUND Head and Neck cancers are conventionally treated with either radical surgery or radiotherapy with curative intent in early stages. In advanced stages, larger doses of radiotherapy is required to achieve cure which requires altered fractionation schedules of radiotherapy like hyperfractionation. This study is conducted to assess the response to hyperfractionation radiotherapy in advanced head and neck cancers. The objective of this study is to compare the Hyperfractionation and Conventional fractionation of Radiotherapy in advanced Head and Neck cancers. Design- Randomised Controlled Study. MATERIALS AND METHODS 60 patients with advanced head and neck cancers attending Govt. Arignar Anna Cancer Hospital, Kancheepuram, were selected and divided equally into Hyperfractionation Radiotherapy arm and Conventional Radiotherapy arm for 6 weeks and treatment response was evaluated. RESULTS In the Hyperfractionation Radiotherapy arm complete response (53%), partial response (37%), minimal response (3%) and stable disease (7%) were noted. In the conventional Radiotherapy arm complete response (30%), partial response (57%), minimal response (7%), stable disease (3%) and tumour progression (3%) were present. CONCLUSION Better locoregional control can be obtained with Hyperfractionation radiotherapy than Conventional radiotherapy, though acute toxicities are more common in the former.
Authors and Affiliations
Ramkumar Bakthavachalam, Vidya Albert Yen
Keywords
Related Articles
- EP ID EP276385
- DOI 10.14260/jemds/2017/1266
- Views 90
- Downloads 0
TRICHOSCOPIC STUDY OF NON-SCARRING ALOPECIA OF THE SCALP
BACKGROUND Trichoscopy is a tool used in the diagnosis of alopecia, but its utility has not been completely assessed. The objective is to study the dermoscopy findings of different types of non-scarring alopecia of the s...
ANALYSIS OF SEMEN STUDIES OF 200 MEN ATTENDING AN INFERTILITY CLINIC IN A TERTIARY CARE CENTRE
BACKGROUND Various characteristics of the male population reporting for infertility evaluation were seen in their semen studies. Aim- To study the various variables of the semen analysis data. MATERIALS AND METHODS Prosp...
ASSESSMENT OF COLORECTAL CARCINOMA WITH EMPHASIS ON OUTCOME OF YOUNG AGED PATIENTS- A STUDY OF 62 CASES
BACKGROUND Colorectal Carcinoma (CRC) is an upcoming aggressive malignancy, especially among young adult population in recent years. This study emphasises on assessing disease burden and its outcome in young age colorect...
ISOLATION AND IDENTIFICATION OF CANDIDA SPECIES IN THE PATIENTS OF UTI
Fungal infections of the urinary tract especially those caused by Candida species are becoming increasingly common due to prolonged antibiotic use, indwelling urinary catheters, and increase in the number of im...
OUTCOME OF CATARACT SURGERY IN A SOFT EYEBALL
Presenting here the outcome of cataract surgery in a 40yr old male patient diagnosed with mature cataract with ocular hypotony. Patient was investigated and all the possible causes of hypotony were ruled out. This wa...