COMPARISON OF HYPERFRACTIONATION AND CONVENTIONAL METHOD OF RADIOTHERAPY IN HEAD AND NECK CANCERS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 84
Abstract
BACKGROUND Head and Neck cancers are conventionally treated with either radical surgery or radiotherapy with curative intent in early stages. In advanced stages, larger doses of radiotherapy is required to achieve cure which requires altered fractionation schedules of radiotherapy like hyperfractionation. This study is conducted to assess the response to hyperfractionation radiotherapy in advanced head and neck cancers. The objective of this study is to compare the Hyperfractionation and Conventional fractionation of Radiotherapy in advanced Head and Neck cancers. Design- Randomised Controlled Study. MATERIALS AND METHODS 60 patients with advanced head and neck cancers attending Govt. Arignar Anna Cancer Hospital, Kancheepuram, were selected and divided equally into Hyperfractionation Radiotherapy arm and Conventional Radiotherapy arm for 6 weeks and treatment response was evaluated. RESULTS In the Hyperfractionation Radiotherapy arm complete response (53%), partial response (37%), minimal response (3%) and stable disease (7%) were noted. In the conventional Radiotherapy arm complete response (30%), partial response (57%), minimal response (7%), stable disease (3%) and tumour progression (3%) were present. CONCLUSION Better locoregional control can be obtained with Hyperfractionation radiotherapy than Conventional radiotherapy, though acute toxicities are more common in the former.
Authors and Affiliations
Ramkumar Bakthavachalam, Vidya Albert Yen
Keywords
Related Articles
- EP ID EP276385
- DOI 10.14260/jemds/2017/1266
- Views 103
- Downloads 0
A COMPARATIVE STUDY OF SURGICALLY INDUCED ASTIGMATISM IN MANUAL SMALL INCISION CATARACT SURGERY AND PHACOEMULSIFICATION IN SENILE CATARACT
BACKGROUND Cataract surgery is the most frequently performed surgical procedure. The surgical outcome in terms of visual acuity depends on surgical technique and type of intraocular lens used. In this article, we are com...
A COMPARATIVE STUDY OF EPIDURAL VOLUME EXTENSION TECHNIQUE VERSUS SPINAL ANAESTHESIA USING HYPERBARIC BUPIVACAINE IN LOWER ABDOMINAL AND LOWER LIMB SURGERIES
BACKGROUND Epidural Volume Extension technique (EVE) via a combined spinal epidural technique is the enhancement of small dose intrathecal block by epidural saline boluses. 1 Epidural volume extension of a small dose spi...
CAN TOPICAL TRANEXAMIC ACID APPLICATION ON PUMP CORONARY ARTERY BYPASS GRAFT SURGERY REDUCE POSTOPERATIVE BLOOD LOSS
BACKGROUND Postoperative blood loss remains a major concern in cardiac surgeries. At least 30% of the times, the cause for blood loss is attributed to diffuse microvascular bleeding. [1] It results from a multifactorial...
KNOWLEDGE, ATTITUDE AND PRACTICE (KAP) OF RUBELLA VACCINATION IN ADOLESCENT GIRLS ATTENDING GYNAECOLOGY OPD AT BRD MEDICAL COLLEGE, GORAKHPUR
BACKGROUND Rubella, also called German measles, is a disease of childhood. In the absence of pregnancy, it is usually clinically manifested as a mild self-limited infection. But a woman infected with the Rubella virus du...
STUDY OF CD4 COUNT IN PRE-ART PERIOD AND DURING ART PERIOD IN SEROPOSITIVE HIV ADULT PATIENTS TO SEE THE EFFECT OF HAART
BACKGROUND Cases of HIV are increasing all over the world. India is the third largest in terms of HIV epidemic. This disease has put economic burden over the country. Hence we conducted this study to compare CD4 Count be...