COMPARISON OF IBUPROFEN RELEASE FROM DIBUTYRYLCHITIN AND POLYLACTIC ACID FILMS
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2009, Vol 0, Issue
Abstract
The polymer films were developed from different materials - biodegradable polymers such as dibutyrylchitin (DBCH) and polylactid (PLA) to determine the release of ibuprofen and swelling kinetics at various pH of the environment. Swelling experiments and ibuprofen release were carried out using two different pH solutions, i.e. acid (pH = 5.6 deionized water solution) and basic ones (pH = 7.2 buffer solution), respectively. The results of the ibuprofen release and swelling properties showed that the processes are varied with the changes of the pH of the solution. The results indicate that the swelling process and release of ibuprofen follow first order kinetics.
Authors and Affiliations
Maria Mucha, Iwona Michalak, Jacek Balcerzak
Keywords
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