COMPARISON OF IBUPROFEN RELEASE FROM DIBUTYRYLCHITIN AND POLYLACTIC ACID FILMS
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2009, Vol 0, Issue
Abstract
The polymer films were developed from different materials - biodegradable polymers such as dibutyrylchitin (DBCH) and polylactid (PLA) to determine the release of ibuprofen and swelling kinetics at various pH of the environment. Swelling experiments and ibuprofen release were carried out using two different pH solutions, i.e. acid (pH = 5.6 deionized water solution) and basic ones (pH = 7.2 buffer solution), respectively. The results of the ibuprofen release and swelling properties showed that the processes are varied with the changes of the pH of the solution. The results indicate that the swelling process and release of ibuprofen follow first order kinetics.
Authors and Affiliations
Maria Mucha, Iwona Michalak, Jacek Balcerzak
Keywords
Related Articles
- EP ID EP73790
- DOI -
- Views 71
- Downloads 0
ELECTROLYTIC METHOD FOR OBTAINING POROUS CHITOSAN STRUCTURES WITH HYDROXYAPATITE
The aim of this study was to develop a preparation method of porous chitosan structures, in the electrolysis of the chitosan solution in acetic acid. Chitosan in aqueous acetic acid is a polyelectrolyte. During the const...
DIFFERENTIAL EFFECTS OF LOW AND HIGH MOLECULAR WEIGHT CHITOSAN ADMINISTERED INTRAPERITONEALLY TO MICE INFECTED WITH HELIGMOSOMOIDES POLYGYRUS
Aim of the study was to compare the effect of different molecular weight chitosan on activity of peritoneal cells of mice during immunosupression caused by adult stages of Heligmosomoides polygyrus. We observed that intr...
BIOPOLYMER COMPOSITES BASED ON LIGNIN AND MICROCRYSTALLINE CHITOSAN
The article presents method of extracting lignin from hardwood and softwood after chemical treatment. Lignin fractions were extracted from black liquid (the by-product of pulp and paper industry), in a different reaction...
SALICYLIC ACID RELEASE FROM CHITOSAN PELLETS COATED WITH POLYLACTIDE
The aim of the study was to prepare a bi-polymer drug carrier composed of chitosan pellets (CS) coated with polylactide shell (PLA) providing prolonged model drug – salicylic acid (SA) release into phosphate buffer of pH...
IN VIVO STIMULATION OF PERITONEAL CELLS BY CHITOSAN ADMINISTERED IN DRINKING WATER TO MICE
The aim of the study was to determine immunostimulant properties of chitosan administered alimentary to BALB/c mice. We observed that chitosan feeding effected in activation of cells from the peritoneal cavity. The cells...