Comparison of in vitro Antibacterial Effects of Cnidoscolus aconitifolius and OcimumgratissimumHydromethanolic Leaf Extracts
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 1
Abstract
The study provided evidence for the ethno-medicinal claims of Chaya and scent leaves. The in vitro antibacterial effect ofCnidoscolusaconitifolius(Chaya) and Ocimumgratissimum (Scent) hydromethanolic leaf extracts were determined and compared. They were tested against pure cultures of clinical isolates of Escherichia coli, Klebsiellaoxytoca,Shigellaflexneri, Salmonella typhi, Staphylococcusaureus, Pseudomonas aeruginosa, Bacillus subtilisandVibrocholerausing agar well diffusion method.Methanol (80%) was used for theSoxhlet extraction of the active constituents of the plants. The susceptibility patterns of the test isolates to the hydromethanolic extracts of Cnidoscolusaconitifolius and Ocimumgratissimum leaves were determined at concentrations of 0.25g/10ml, 0.5g/10mland 1g/10ml. The results showed that the antibacterial activities of the extracts were concentration dependent and vary with each isolate. The zones of inhibition of the extracts were compared with a standard antibiotic (Chloramphenicol).It was observed that the total percentage bacterial inhibitionof Cnidoscolusaconitifoliuscompared with Chloramphenicol was higher (67.39%) than that ofOcimumgratissimum (45.61%).This affirmed the traditionaluse of both leaves for prophylaxis or treatment of infectious diseases. The work suggested further identification and isolation of the bioactive antibacterial compounds fornewer drug development.
Authors and Affiliations
Iwuji Samuel Chidi, Okoro, Ijeoma Amarachi, Ndubuka Gideon Ihebuzo, Banigo Alma, Ekezie Jervas, Agbai Emmanuel
Keywords
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- EP ID EP452705
- DOI 10.9790/0853-1801197380.
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