Comparison of inhibitory effect of ibuprofen with Piper guineense Schumach and Thonn. on some reproductive hormones in female rats
Journal Title: The Journal of Phytopharmacology - Year 2017, Vol 6, Issue 4
Abstract
The aim of the present study was to compare the inhibitory effect of ibuprofen with oral administration of Piper guineense leaf extract on follicle-stimulating hormone, luteinizing hormone, progesterone and estrogen in female rats irrespective of the estrous cycle. The animals were randomly assigned to four groups (n = 7): group A (control), Group B, 180 mg-kg of ibuprofen, Group C, 200 mg-kg of Piper guineense extract, Group D, 180 mg-kg of ibuprofen and 200 mg-kg of Piper guineense extract. At the end of two weeks administration, rats were sacrificed under urethane anesthesia and hormones measured using enzyme-linked immunosorbent assay method. Results showed significant reduction in serum follicle-stimulating hormone and luteinizing hormone following ibuprofen administration in Group B rats at P < 0.05. Piper guineense extract treated Group C rats caused significant reduction in serum luteinizing hormone and progesterone at P < 0.05. In contrast, serum follicle stimulating hormone significantly increased in Group D rats at P < 0.05 whereas serum luteinizing hormone and progesterone were markedly reduced at P < 0.05. Serum estrogen level remained unchanged among groups. In conclusion, results obtained suggested that extract inhibited luteinization of follicles thus could impair ovulation, therefore the extract can be used as oral contraceptive in family planning.
Authors and Affiliations
Emmanuel Onuka AGBAI, Chisomaga Chiwuikem EKE, Collins Okechukwu NWANEGWO, Ugochukwu Bond ANYAEHIE
Keywords
Related Articles
- EP ID EP49739
- DOI -
- Views 166
- Downloads 0
An examination of the consequences of chronic exposure to Mitragyna speciosa during adolescence on learning and memory in adulthood
Although an emerging drug of concern in the United States and Europe, the active alkaloids associated the Mitragyna speciosa plant have long been utilized for a number of purposes ranging from use as an antitussive to...
Hypoglycemic effect of Helichrysum odoratissimum in alloxan induced diabetic mice
Diabetes mellitus is a disease of antiquity with worrying global incidence and prevalence. Conventional management and/or treatment interventions have been hampered by drawbacks like high costs, inaccessibility, likeli...
Ethnomedicinal survey of plants used by tribal in Lalgarh forest range, W.B., India
Exploration of the traditional knowledge of the indigenous people is very important for revealing the uses of plants and plant parts for medicinal purpose. Once the medicinal use of these plants is known, their active...
General overview of medicinal plants: A review
Medicinal plants have been playing an essential role in the development of human culture. As a source of medicine, Medicinal plants have always been at forefront virtually all cultures of civilizations. Medicinal plant...
Butyrylcholinsterase inhibitors from two Ficus species (Moraceae)
Alzheimer’s disease (AD) is the most common form of dementiaand mainly afflict people over 65 years of age. AD is characterized by a progressive memory loss that leads to a profound emotional disturbance in later stage...