Comparison of inhibitory effect of ibuprofen with Piper guineense Schumach and Thonn. on some reproductive hormones in female rats
Journal Title: The Journal of Phytopharmacology - Year 2017, Vol 6, Issue 4
Abstract
The aim of the present study was to compare the inhibitory effect of ibuprofen with oral administration of Piper guineense leaf extract on follicle-stimulating hormone, luteinizing hormone, progesterone and estrogen in female rats irrespective of the estrous cycle. The animals were randomly assigned to four groups (n = 7): group A (control), Group B, 180 mg-kg of ibuprofen, Group C, 200 mg-kg of Piper guineense extract, Group D, 180 mg-kg of ibuprofen and 200 mg-kg of Piper guineense extract. At the end of two weeks administration, rats were sacrificed under urethane anesthesia and hormones measured using enzyme-linked immunosorbent assay method. Results showed significant reduction in serum follicle-stimulating hormone and luteinizing hormone following ibuprofen administration in Group B rats at P < 0.05. Piper guineense extract treated Group C rats caused significant reduction in serum luteinizing hormone and progesterone at P < 0.05. In contrast, serum follicle stimulating hormone significantly increased in Group D rats at P < 0.05 whereas serum luteinizing hormone and progesterone were markedly reduced at P < 0.05. Serum estrogen level remained unchanged among groups. In conclusion, results obtained suggested that extract inhibited luteinization of follicles thus could impair ovulation, therefore the extract can be used as oral contraceptive in family planning.
Authors and Affiliations
Emmanuel Onuka AGBAI, Chisomaga Chiwuikem EKE, Collins Okechukwu NWANEGWO, Ugochukwu Bond ANYAEHIE
Keywords
Related Articles
- EP ID EP49739
- DOI -
- Views 156
- Downloads 0
Natural product medicines: A literature update
Natural products represent major approach for the discovery and development of new drugs. An updated review on the natural products is lacking in the literature. So, in the present review, an attempt has made to pool t...
Protective effect of Mollugo cerviana extract on liver markers in alloxan induced diabetic rats
Diabetes mellitus is a metabolic disorder of multiple aetiology characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin...
Madhuca longifolia water extract revealed protective effect against MES, PTZ and Li-pilocarpine induced epilepsy
Objective: Present study was designed to screen the antiepileptic property of aqueous extract of Madhucalongifolia (AqML) in laboratory animals. Materials and methods: Rat and mice were divided in different groups. Ant...
Resistance modulation studies of vernolide from Vernonia colorata (Drake) on ciprofloxacin, amoxicillin, tetracycline and erythromycin
Resistance modulatory activities of natural products on traditional antibiotics have gained scientific interest in recent years. This is aimed at maximizing antimicrobial potency with major strides in curbing microbial...
Analyzing the phytochemical composition of Justicia neesii Ramam)
Phytochemical profile is an important aspect as it will give an over view of possible pharmacological properties of the plant. Justicia neesii is a plant belongs to Acanthaceae family, on which no significant phytochem...