Comparison of Insulin Tolerance Test with Various Simple and Safe Methods in the Prediction of Insulin Sensitivity
Journal Title: Turkish Journal of Endocrinology and Metabolism - Year 1998, Vol 2, Issue 3
Abstract
In the measurement of insulin sensitivity, intravenous insulin tolerance test (IVITT) has been shown to have a high correlation with the euglycemic hyperinsulinemic clamp method. We compared IVITT with levels of plasma Insulin/Glucose ratio (IGR), levels of plasma Insulin/C-peptid ratio (ICR), fasting and 1-h post load insulin levels in 58 nondiabetic obese subjects (Mean BM1: 28.8±1.6 kg/m2, age: 42.8±8.5 years). The glucose levels were determined at 3 min intervals for 15 min after insulin injection. insulin sensitivity was estimated with blood glucose disappearance rate (KITT).KITT 3.51±2.38 % min-1; fasting and post load IGR 35±20, 139±74 pM/mM; fasting and post load ICR 0.14±0.13, 0.25±0.15 pM; fasting and postload 1-h insulin levels were 124.2±48, 882±364 pM, respectively. KITT correlated only with fasting insulin level (r=0.52, p<0.05) and fasting IGR (r= -0.47, p<0.05). Fasting insulin level correlated with 1-h post load insulin level (r=0.58, p<0.05). Fasting IGR correlated with 1-h post load IGR (r=0.55, p<0.05) and fasting ICR (r=0.65, p<0.05). Fasting ICR correlated with 1 -h post load ICR (r=0.67, p<0.001). As a result fasting/postglucose 1 -h insulinaemia has been found very useful in measuring insulin sensitivity, practically. But the ratio of insulinaemia/glycaemia (IGR) appeared to be simple and better method in terms of good correlation with KITT.
Authors and Affiliations
Yüksel Altuntaş, Üstün Korugan, Nezih Hekim
Keywords
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