Comparison of Intra-Operative ECG Variations (QRS and PR Interval Prolongation) Between 0.25% Ropivacaine and 0.25% Bupivacaine in Patients Undergoing Lower Limb Surgery under Epidural Blockade
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 8
Abstract
Background: Ropivacaine, new aminoamide local anaesthetic (LA) drug, is chemically homologous to bupivacaine. The lower lipid solubility and higher clearance of ropivacaine compared with bupivacaine is presumed to retard penetration of myelin sheaths, leading to a decreased potential for neural and cardiac toxicity. This may offer an advantage in terms of systemic toxicity. Experimental studies and case reports confirm this hypothesis, showing that ropivacaine causes fewer cardiotoxic effects and is better alternative to bupivcaine. Material & Method: Thirty ASA grade I and II patients of either sex, aged between 20 -50 years undergoing elective lower limb surgeries were enrolled in each group using double-blind randomization. Each group received 0.25%, 25 ml of either bupivacaine or ropivacaine with 18 G needle as single shot epidural injection. A sensory level of T10 was achieved. Variations in heart rate, arterial blood pressure and ECG (PR interval & QRS prolongation, ectopics, arrhythmias) were recorded before epidural injection, 10 minutes after epidural injection and thereafter every 10 minutes interval till the end of surgery. Result: This study showed that epidural ropivacaine produced ECG changes which were substantially similar to those produced by equipotent concentrations and doses of bupivacaine. Conclusion: ECG changes in terms of ventricular arrhythmias, QRS and P-R interval were clinically similar in both groups.
Authors and Affiliations
Dr A K Sinha
Keywords
Related Articles
- EP ID EP214226
- DOI -
- Views 79
- Downloads 0
A Correlational Study of Serum Lipoprotein (A) Level and Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients
Background and Objectives: Diabetes is the most common endocrine disorder and a burdensome chronic disease in the world today. The objective of the study is to assess the Microvascular complication-diabetic nephropathy i...
Effect of Midazolam and Propofol in Prevention of Emergence Agitation in Paediatric Patients Under Sevoflurane Based Anaesthesia: A Comparative Study
Introduction: Sevoflurane is the most commonly used inhalational anaesthetic agent in paediatric setup. The incidence of emergence agitation (EA) is high in children after sevoflurane anaesthesia. The efficacy of propofo...
Metabolic Encephalopathy in Elderly with a Special Focus on Thyroid Function and Hashimotos Encephalopathy
Objective: Metabolic encephalopathy is a common cause for morbidity and mortality in elderly. Metabolic disturbances are frequent causes of impaired consciousness and their presence must always be considered when there a...
Application of Social Network Analysis in Diverse Health and Allied Disciplines –A Review of Existing Research Literature
Social network analysis is the study of social structure which connects individuals. This paper reviews the scopes and use of social network analysis as a tool for health research and interventions for improving the heal...
Study of Pre-Analytical and Post-Analytical Errors in Hematology Laboratory in A Tertiary Care Hospital
Introduction: Laboratories play an important role in the diagnosis and management of the disease. In the modern day diagnostics, with the advent of technologies and automation in the laboratories, the manual workload has...