Comparison of Intrathecal Magnesium Sulphate and Intrathecal Buprenorphine Used as Adjuvants to Hyperbaric Bupivacaine: A Prospective Randomized Double Blind Placebo Controlled Study
Journal Title: Journal of Anesthetic Research and Pain Medicine - Year 2016, Vol 1, Issue 1
Abstract
Magnesium has advantages compared to other adjuncts to local anaesthetics in spinal anaesthesia. This study is designed to compare the effects of intrathecal magnesium sulphate with buprenorphine as adjuvants to bupivacaine. 90 adult patients scheduled for below umbilicus surgeries were randomized into three groups of 30 each. They received 2.75ml of 0.5% hyperbaric bupivacaine mixed with either 0.5ml of 10% magnesium sulphate(50mg) or 0.5ml of buprenorphine(150µg) or 0.5ml of sterile water(placebo). Onset, duration of sensory and motor block and duration of total analgesia were studied. The duration of spinal anaesthesia did not increase with the addition of magnesium, but did so with buprenorphine. The time for first analgesic request was 493.33 > 313.1 > 234.17 mins (buprenorphine > magnesium > placebo) p<0.001. Addition of 50mg magnesium sulphate to bupivacaine did not demonstrate an effect on duration of spinal anaesthesia. However, it significantly prolonged the time for first analgesic request though to a lesser extent than buprenorphine, thus substantiating its use in postoperative analgesia.
Authors and Affiliations
Kaushic A Theerth, Madhuri S. Kurdi
Keywords
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- EP ID EP248901
- DOI 10.28967/jarpm.2016.01.16002
- Views 122
- Downloads 0
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