Comparison of Intubating Conditions with 0.6 mg/kg and 0.9 mg/kg Rocuronium Bromide for Rapid Sequence Intubation
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2017, Vol 6, Issue 2
Abstract
Introduction: Dose of rocuronium bromide usually used for rapid sequence intubation (RSI) allows rapid paralysis but the duration of action is prolonged making it unsuitable for short duration surgeries. Theoretically, use of low doses of neuromuscular blocking agents shortens the time for recovery from neuromuscular blockade (NMB). Hence we studied the intubating conditions of rocuronium bromide at 2 × ED95 dose (0.6 mg/kg) in comparison with 3 × ED95 dose (0.9 mg/kg). Methods: Sixty patients aged 18-60 years, ASA PS 1 and 2 posted for elective surgeries requiring GA with endotracheal intubation were studied. Patients were randomized into two groups of 30 each (Group A and B), to receive either 0.6 mg/kg rocuronium bromide or 0.9 mg/kg rocuronium bromide. Intubating condition was assessed at 60 seconds. Onset and clinical duration were recorded and data analysed using independent sample t-test and chi-square analysis. Results: There was a signifcant difference in the intubating conditions between the groups (p=0.001) with 28 patients (93.3%) having excellent intubating conditions and 2 (6.6%) having good intubating conditions in Group B whereas 16 patients (53.3%) had excellent intubating conditions and 12 (40%) had good intubating conditions in Group A. None had inadequate conditions for intubation. There was signifcant difference (p<0.0001) between the mean clinical duration of NMB in group A (29.37 min ± 5.73 min) and Group B (50.10 min ± 6.69 min). Conclusion: We concluded that rocuronium bromide at 0.9 mg/kg provided good to excellent intubating conditions at 60 seconds but at the cost of prolonged duration of NMB. Whereas rocuronium bromide at 0.6 mg/kg provided adequate intubating conditions for RSI at 60 seconds and hence could be used at this dose in situations where succinylcholine is contraindicated and a shorter duration of NMB is preferred.
Authors and Affiliations
Brijesh Savidhan| Department of Anaesthesiology, Travancore Medical College, Kollam, India, Corresponding e-mail: brijesh_savidhan@yahoo.com, Marina Kuruvilla| Department of Anaesthesiology and Critical Care, Lourdes Hospital, Kochi, India, Shobha Philip| Department of Anaesthesiology and Critical Care, Lourdes Hospital, Kochi, India
Keywords
Related Articles
- EP ID EP12314
- DOI -
- Views 337
- Downloads 16
Male infertility in Western Region of India: a cytogenetic study of 112 patients with impaired spermatogenesis
Background: Male infertility due to severe oligozoospermia and azoospermia has been associated with a number of genetic factors. Chromosomal abnormalities are one of the principle genetic factors in male infertility. Pur...
COST ANALYSIS STUDY OF ORAL ANTIDIABETIC DRUGS AVAILABLE IN INDIAN MARKET
Introduction: There exists a wide range of variation in the prices of drugs marketed in India and other countries of the world. Very few studies have been conducted to reveal such price variations in the open market. A...
RPOB gene mutation in rifampicin resistant MRSA from foot infections of patients having diabetes mellitus
Staphylococcus aureus is an opportunistic bacterial pathogen associated with asymptomatic colonization of the skin and mucosal surfaces of normal humans. Staphylococcus aureus isolates are often multidrug resistant. Rif...
Investigating students’ attitude and performance of smoking at Hormozgan University of Medical Sciences in 2015
Background and purpose of the study: Willingness to smoke and the negative consequences of smoking are among the main problems in general health all around the world. Therefore, the present research attempted to investi...
Impact of Predisposing Factors on Academic Stress among Pre-Service Teachers
Background: Many studies have been done on stress among educators. Teachers, lecturers, and tutors all over the world has been brought into attention when it comes to stress related issues. Our purpose was to investigat...