Comparison of Ketamine Intravenous Infusion with Dexmedetomidine Intravenous Infusion to Alleviate Propofol Injection Pain.
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 3
Abstract
Background and Aims: For induction of anaesthesia propofol is the most widely used intravenous anaesthetic agent. The induction of anaesthesia is rapid with propofol and also is recovery .But propofol injection pain (PIP) still remains a problem. The incidence of pain on its injection is 28-90%. The high prevalence of pain makes it necessary to find an ideal drug or drug combination to alleviate the pain on propofol injection. The aim of this study was to compare ketamine 0.5 mg/kg intravenous (IV) infusion with dexmedetomidine 0.5mcg/kg IV infusion to alleviate PIP. Methods: In this prospective observational study 70 patients undergoing elective surgeries under general anaesthesia were randomly enrolled to two groups. 35 patients (group K) received ketamine 0.5 mg/kg IV and 35 patients (group D) received dexmedetomidine 0.5mcg/kg in 20ml normal saline over 10 minutes. Soon after the infusion, 1% propofol 2mg/kg IV was injected over 25 seconds. The pain was assessed by asking ‘does it hurt’ every 5 seconds, until the patient lost consciousness. McCririck and Hunter scale was used for pain scoring. Statistical analysis done-usingSPSS 22 version. Results: 97.1% of patients in group K had no PIP where as 2.9% of group D had no PIP. In the dexmedetomidine group, 17.06% had severe pain, 37.12% had moderate pain. The incidence of PIP was significantly higher in group D compared to group K (P<0.05) Conclusion: IV ketamine infusion is more effective than IV dexmedetomidine infusion to alleviate PIP.
Authors and Affiliations
Dr. Regimol V. Varghese
Keywords
Related Articles
- EP ID EP511545
- DOI -
- Views 59
- Downloads 0
Experience of Uterine Rupture in A Tertiary Care Institute: A Systematic Review of the Literature
Rupture of gravid uterus is one of dreaded and catastrophic complication frequently dealt in the developing countries which requires a high index of suspicion. This article explore four cases of uterine rupture and the m...
A Study on MRSA Isolates in MCH Microbiology Lab, Medical College Hospital, Thiruvanantapuram
Methicillin Resistant Staphylococcus aureus (MRSA) were noticed in 1961 and they developed into a Health-care associated organism throughout the world. Recently the appearance of endemic Communityacquired MRSA has been r...
A Study of Maternal and Perinatal Outcome in Pre Labour Rupture of Membranes at Term
Introduction: Prelabour Rupture of Membranes (PROM) is defined as the rupture of fetal membranes with a latent period before the onset of spontaneous uterine activity. The length of this latent period varies in different...
Study of Leptin and Adiponectin in Type 2 Diabetes Mellitus
Introduction: The diabetes mellitus is a metabolic disorder and forthcoming epidemic all over the globe that is caused due to insulin resistance. In this background the adipokine-leptin could be potential and beneficial...
Spectrum of Magnetic Resonance Imaging Findings in Spinal Tuberculosis
Aim: To describe the radiological features of spinal tuberculosis on Magnetic Resonance Imaging and study the role of MRI in assessing the extent of disease. Materials and Methods: This was a descriptive study conducted...