Comparison of Ketorolac Tromethamine and Prednisolone Acetate in Preventing Surgically Induced Miosis during Cataract Surgery
Journal Title: Sultan Qaboos University Medical Journal - Year 2010, Vol 10, Issue 1
Abstract
Te aim of this study was to compare the efcacy and safety of topical prednisolone acetate 1% and topical ketorolac tromethamine 0.5% in the maintenance of pupillary mydriasis during cataract surgery. Methods: Fifty patients were enrolled in this prospective, partially masked and randomised study. Tey were assigned to receive topical treatment with either prednisolone acetate (n = 25) or ketorolac tromethamine (n = 25), starting 24 hours before cataract extraction (either routine extracapsular cataract extraction or phacoemulsifcation). One drop of the study medication was instilled every 6 hours for a total of 4 drops. No epinephrine was used in the intraoperative irrigation solution. Pupil diameter was measured three different times during surgery. To ensure participant safety, biomicroscopy, ophthalmoscopy, intraocular pressure, adverse events and visual acuity were also monitored. Results: Te mean pupil diameter change from the time of the pre-incision until after cortical irrigation and aspiration and lens implantation was signifcantly less with ketorolac than with prednisolone (P = 0.003). Consequently, mean pupil diameter after cortical irrigation and aspiration and lens implantation was signifcantly greater with ketorolac than with prednisolone (P <0.0001). No signifcant differences between groups were observed in the pupil diameter before the frst incision (P = 0.244), nor after administration of a miotic agent (P = 0.505). Safety variables were comparable and no drug-related adverse events were reported. Conclusion: Ketorolac tromethamine 0.5% and prednisolone acetate 1% solutions were equally well tolerated without related adverse events, but ketorolac was better in preventing surgically induced miosis.
Authors and Affiliations
Yusuf M Suleiman| Department of Ophthalmology, Al-Assad Hospital, Tishreen University, Latakia, Syria, Najwa F Krdoghli| Department of Ophthalmology, Al-Assad Hospital, Tishreen University, Latakia, Syria, Aksam J Ahmad| Department of Ophthalmology, Al-Assad Hospital, Tishreen University, Latakia, Syria
Keywords
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