Comparison of levobupivacaine and clonidine with plain levobupivacaine in spinal anaesthesia in lower limb surgeries

Journal Title: Medpulse International Journal of Anesthesiology - Year 2017, Vol 3, Issue 1


Background: Intrathecal Levobupivacaine is having similar clinical profile with less cardio-toxicity than Bupivacaine is used commonly in lower limb surgeries. Clonidine as an additive to LA provides effective prolongation and dose dependent analgesia. Aim: To compare effect of intrathecal 0.5% Levobupivacaine heavy 10 mg with Clonidine 30 µg with 0.5% levobupivacaine 10mg for lower limb surgeries. Material and Method: In this study we compared onset, degree, maximum sensory level achieved, time required to achieve the maximum level of sensory blockade, duration of effective sensory blockade and onset and degree of effective motor blockade and post-operative analgesia. Results: The onset of Analgesia and motor block started at 2.25±0.19 and 8.51± 0.18 minutes in group I and slightly delayed 2.48±0.18 and 9.33±0.14 minutes in control group mean duration of two segment regression in clonidine group was 210.51±6.99 minutes and in control group was 124.83±5.098 minutes, duration of motor blockade in clonidine group is 220.17±9.68 minutes and in control group is 155.34±6.262 minutes. The mean duration of analgesia in clonidine group is 650.17±9.26 minutes and in control group is 230.86±26.22 minute. The prolongation in duration of analgesia in clonidine group was statistically more significant (p<0.05). Conclusion: We observed that that isobaric Levobupivacaine with Clonidine has got comparable pharmacokinetic in onset of sensory and motor block, good intraoperative and postoperative prolonged analgesia.

Authors and Affiliations

Sudeep 1, N Gopal Reddy


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  • EP ID EP260413
  • DOI -
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How To Cite

Sudeep 1, N Gopal Reddy (2017). Comparison of levobupivacaine and clonidine with plain levobupivacaine in spinal anaesthesia in lower limb surgeries. Medpulse International Journal of Anesthesiology, 3(1), 27-30.