COMPARISON OF LONG ACTING β2 - AGONISTS IN THE ASTHMATIC PATIENTS AND ASSESSMENT OF THEIR KNOWLEDGE, ATTITUDE AND PRACTICE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 10
Abstract
The study was conducted to evaluate the efficacies of the three long acting beta2-agonists (Salmeterol, Formoterol and Bambuterol) in south Indian population. This prospective multi-centered study conducted in various hospitals on basis of block randomization method using St. George’s respiratory questionnaire and assess pulmonary function using spirometer. Out of 85 patients, 25 received Salmeterol, 35 received Formoterol and 25 received Bambuterol, showed variable improvement in the quality of life from baseline and clinical improvements. Change in overall scores from baseline was 56.33 units for Salmeterol, 61.91 units for Formoterol and 54.54 units for Bambuterol. Pulmonary function tests showed a better result for Salmeterol. Knowledge, attitude and practice of patients were improved at the end of the study and showed better compliance that had a good impact on the quality of life of the patients. Salmeterol has shown a better improvement and correlation in case of both quality of life and pulmonary function tests, when compared with others. Formoterol showed a better quality of life but a correlation with the pulmonary function tests was not seen like Salmeterol. The proportion of patients showed increase in knowledge, attitude and practice as well as the compliance by the end of the study.
Authors and Affiliations
Sundaran Siraj , N. Premkumar, S. D. Rajendran, S. Saji
Keywords
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