Comparison of Nitroglycerin versus Lignocaine Spray to Attenuate Haemodynamic Changes in Elective Surgical Patients Undergoing Direct Laryngoscopy and Endotracheal Intubation: A prospective randomised study
Journal Title: Sultan Qaboos University Medical Journal - Year 2019, Vol 19, Issue 4
Abstract
Objectives: This study aimed to compare the effects of nitroglycerin (NTG) versus lignocaine spray in blunting the pressor response during direct laryngoscopy and endotracheal intubation. Methods: This study was conducted between January and June 2018 in the Department of Anesthesiology, Teerthankar Mahaveer Medical College, Moradabad, India. A total of 90 elective surgical patients of American Society of Anesthesiologists physical status grades I or II were divided into three groups, comprising two treatment groups and one control group. Patients in the treatment groups received either one puff (1.5 mg/kg) of lignocaine 10% spray or one puff (400 μg) of NTG spray in the oropharynx one minute prior to the induction of anaesthesia. Haemodynamic variables and mean rate pressure product at baseline and one, two, three, four and five minutes post-induction were compared. Results: There was a significant reduction in mean heart rate at 3–5 minutes in both treatment groups compared to the control group (P <0.050), as well as lower increases in mean arterial pressure at 1–3 minutes (P <0.050). However, at 2–4 minutes, there was a significantly greater decrease in mean systolic blood pressure in the NTG group compared to both the lignocaine and control groups (P <0.050). Moreover, a greater decrease in mean rate pressure product response at 1–5 minutes was observed in the NTG group compared to the lignocaine and control groups (P = 0.001). Conclusion: The NTG spray was more effective than lignocaine in attenuating blood pressure increases and rate pressure product during elective laryngoscopy and intubation.
Authors and Affiliations
Rohit K. Varshney, Mukesh K. Prasad, Megha Garg
Keywords
Related Articles
- EP ID EP675781
- DOI http://dx.doi.org/10.18295/squmj.2019.19.04.007
- Views 275
- Downloads 0
Trichilemmal Cyst of the Penis in a Paediatric Patient
Paediatric penile cysts are uncommon. We report a fve-year-old child with an asymptomatic progressively growing cyst on the ventral aspect of the penis after a hypospadias repair. Te patient presented to the Cooper Hea...
Notice of Authorship Retraction Use of prophylactic inferior vena cava flters in trauma
Prevalence of Rabies in Various Species in Yemen and Risk Factors Contributing to the Spread of the Disease
Objectives: Tis study aimed to describe for the frst time the prevalence of the passively-reported rabies virus among different domestic and wild animals submitted to the Central Veterinary Laboratory from various are...
Diabetes Care in Oman Obstacles and solutions
Diabetes has become one of the most challenging chronic diseases with its prevalence increasing in most countries worldwide. Te Arabian Gulf countries face a similar increasing prevalence of diabetes. Diabetes care req...
Is More Nutrition Education Needed in the Undergraduate Medical Curriculum? Perceptions of graduates from a medical university in the United Arab Emirates
Objectives: Te rise in lifestyle diseases has resulted in primary physicians advising more patients on the benefts of nutritional modifcations. However, nutrition education has remained more or less unchanged in the un...