COMPARISON OF NMP22 URINARY MARKER TEST AND URINE CYTOLOGY IN THE EARLY DETECTION OF RECURRENT TRANSITIONAL CELL CARCINOMA OF URINARY BLADDER
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2017, Vol 6, Issue 9
Abstract
Background: Urinary Bladder Cancer is the second most common cancer treated by urologists. Its incidence is increasing with age and exposure to environmental toxins. Smoking is a known risk factor. the gold standard of diagnosis of bladder cancer non invasively by urine cytology and invasively by cystoscopy with biopsy for histopathological examination. NMP22 is a tumor marker found in urine that had high sensitivity in detecting low grade and early stage urothelial carcinoma. Aim: To assess clinical utility of NMP22 Bladder Check Test and to compare it with voided urine cytology in early detection of recurrent Bladder Cancer. Patients & Methods: A total of 125 patients of follow up cases of Bladder Cancer were enrolled in this study. Urine samples were assayed for the presence of NMP22 using NMP22 Bladder Check Test and Cytology was performed by a cytopathologist. The diagnosis, determined from the Cystoscopic findings and biopsy findings of the suspicious lesion was considered as the gold standard. For positive biopsies, the results of the NMP22 Test and cytology were also correlated with tumor grade and Stage. Results: From 125 patients, a total number of 59 patients who were positive in cystocopy with histopathological examination which represent the gold standard in our study. Mean age of the patients was 63 years for males and 67 years for females. The NMP22 test was positive in 45 cases and cytology in 21 cases. The sensitivity of NMP22 Test in recurrent bladder cases was 83.3% which was significantly greater than that of cytology 39.5%. In non-invasive lesions of Bladder Cancer (Ta,T1), NMP22 Test and Cytology was positive in 92.5% and 44% of cases respectively. In muscle invasive lesions, NMP22 Test and cytology were equal(100%). The sensitivity of the NMP22 test in low grade tumors (GI,GII) was 75%, which was significantly greater than that of cytology 28%, wherease in high grade tumors (GIII) the sensitivity of NMP22 and cytology were nearly equal (90.9%versus 81.8%) respectively. Conclusion: The NMP22 Bladder Check is a new point of care diagnostic test for urinary bladder cancer. The results of our study have shown that the NMP22 can be used as a follow up tool with urine cytology as we detected high sensitivity and specificity of NMP22 in recurrent bladder cases especially effective in low grade disease where the cytology sensitivity is low but at this time NMP22 cannot replace cystoscopy surveillance from patients with history of bladder cancer.
Authors and Affiliations
Dr. Abdul Rahman Abdul Mhdai
Keywords
Related Articles
- EP ID EP618640
- DOI -
- Views 150
- Downloads 0
REGULATORY GUIDELINES FOR APPROVAL OF BIOSIMILARS IN INDIA, UNITED STATES AND EUROPE - A COMPREHENSIVE SUMMARY
A biosimilar is a biological medicine similar, but not identical, to an already registered reference bio therapeutic product in terms of quality, safety, and efficacy. These drugs are also called as biosimilar products,...
ISOLATION AND CHARACTERIZATION OF EIMERIA SPECIES IN POULTRY USING CONVENTIONAL METHODS AND COCCIMORPH PROGRAM IN KHARTOUM STATE, SUDAN
An outbreak of Coccidiosis has a very high negative and economic impact on the flock as well as for the poultry producer as treatment alone cannot prevent the economic losses. This study was carried out in Khartoum State...
QUANTUM MODELING TO DETERMINE THE CARCINOGENIC POTENTIAL OF AFLATOXIN B2 PRODUCED BY ASPERGILLUS FLAVUS AND A. PARASITICUS
Aflatoxin B2 (AFB2) is produced mainly by the mycotoxin Aspergillus flavus and, Aspergillus parasiticus. Aflatoxins are toxic substances produced by some types of fungi that can grow in food. People who eat foods that co...
FORMULATION AND CHARACTERIZATION OF OIL NANO-EMULSION BASED GEL FOR DERMATOLOGICAL APPLICATION
Essential oil are one of the most notorious natural products used for medical purposes. Collective with their popular use in dermatology. The spontaneous emulsification, micro fluidization and ultra-sonication were compa...
A REVIEW ON PHARMACOLOGICAL IMPORTANCE OF LEAFY GREENS-MEDIATED SILVER NANOPARTICLES
In the present scenario, herbs have created a revolution symbolizing the importance and safety, in contrast to the synthetic drugs all over the world. Nearly 25% modern medicines are derived from plants as their first li...