COMPARISON OF NON-INVASIVE FIBROSIS SCORES BETWEEN ALCOHOLIC LIVER DISEASE PATIENTS AND HEALTHY NON-ALCOHOLICS IN SOUTH INDIAN POPULATION
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2019, Vol 6, Issue 31
Abstract
BACKGROUND Alcoholic Liver Disease (ALD) is a spectrum of disorders ranging from simple steatosis to steatohepatitis and cirrhosis. Various non-invasive markers have been validated as reliable prognostic markers of fibrosis in Chronic Viral Hepatitis and Non-Alcoholic Fatty Liver Disease but their utility in ALD is least evaluated. This study aims to compare the fibrosis scores in ALD patients with non-alcoholic healthy controls. METHODS The non-invasive scores of fibrosis namely AST/ALT ratio, BARD score, APRI and FIB-4 were calculated in 30 ALD cases and 30 age matched controls. Alcohol drinking pattern was evaluated using the AUDIT questionnaire. The difference in the fibrosis scores between cases and controls were calculated using independent student’s t test. All statistical analysis were done using SPSS software v 20.0 and p value <0.05 was considered statistically significant. RESULTS All the non-invasive scores of fibrosis viz. AST/ALT ratio, BARD score, APRI and FIB-4 were significantly high in ALD cases compared to controls. All the cases had AST/ALT ratio more than >1, 76% of them had BARD score >2, 97% had APRI score >1 and 73% had FIB–4 score >3.25 denoting the presence of significant fibrosis in ALD patients. AUDIT score correlates with all the non-invasive fibrosis scores except AST/ALT ratio. There is significant correlation between FIB-4 score and APRI score (r= 0.962, p=<0.001) and between FIB-4 score and AST/ALT ratio (r= 0.500 p= 0.005). CONCLUSIONS The non-invasive fibrosis markers are significantly high in ALD cases. APRI, FIB4 and BARD score positively correlate with alcohol drinking pattern. Hence these scores derived from routine lab investigations could be used as cost effective tools to assess the severity of fibrosis in ALD patients.
Authors and Affiliations
Subramaniam Arulvijayavani, Anbalagan Anithasri, Sivaneshan Harini
Keywords
Related Articles
- EP ID EP670389
- DOI 10.18410/jebmh/2019/424
- Views 78
- Downloads 0
DYNAMICS OF LOWER LID MALPOSITIONS
Lower lid malpositions form amongst the most common lid malpositions encountered in ophthalmic practice. The bilaminar structure of the eye lid is central to the understanding of the mechanism of development, identificat...
COMPARATIVE STUDY OF LAPAROSCOPIC HYSTERECTOMY WITH TOTAL ABDOMINAL HYSTERECTOMY
BACKGROUND Hysterectomy is the second most commonly performed major surgical procedure on women all over the world, next only to caesarean. The purpose of the present study was to compare the outcome between laparoscopic...
SUCCESS RATE COMPARISON OF EXTERNAL DACRYOCYSTORHINOSTOMY WITH AND WITHOUT SILICONE INTUBATION FOR THE TREATMENT OF PRIMARY NASOLACRIMAL DUCT OBSTRUCTION
Epiphora is an annoying symptom embarrassing the patient socially and functionally and is the main symptom of NLDO. This study was conducted to compare the success rate of External DCR with and without silicone intubatio...
PTERYGIUM EXCISION IN COMPARISON OF BARE SCLERA TECHNIQUE AND CONJUCTIVAL AUTOGRAFT
INTRODUCTION: Pterygium is a degenerative condition of the subconjuctival tissue which proliferates as vascularized granulation tissue to invade the cornea, destroying the superficial layers of the stroma and bowmans mem...
ACUTE KIDNEY INJURY IN SEPSIS PATIENTS- AN OBSERVATIONAL STUDY
BACKGROUND Severe sepsis and acute kidney injury (AKI) are both common syndromes that are encountered in the emergency settings. The proportion of patients presenting with severe sepsis upon admission has been reported t...